Protein Alignment TkR86C and GALR2

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_003848.1
• Gene: GALR2 / 8811
• HGNCID: 4133
• Length: 387
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 98/326 - (30%)
• Similarity: 157/326 - (48%)
• Gaps: 56/326 - (17%)

  Fly    80 WE-QKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNF-- 141
            |. :..|..::|.|:..|...||.:||.::.......:.||.|:|||.:|||..  :.|...|
Human    21 WHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCF--ILCCVPFQA 83

  Fly   142 -IFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSR--RKVRIILV 203
             |:.|:. |.|||:.|...:|:..:|:..|.|||.|:|.|||:||.:||..|..|  |.....:.
Human    84 TIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIG 147

  Fly   204 LIWALSCVLSAPCLLYSSIMTKHYYNGK--SRTVCFMMW--PDGRYPTSMADYAYNLIILVLTYG 264
            |||.||.:.|.|.|.|       |...:  :.|||...|  |..|        |.::...|.:|.
Human   148 LIWGLSLLFSGPYLSY-------YRQSQLANLTVCHPAWSAPRRR--------AMDICTFVFSYL 197

  Fly   265 IPMIVMLICYSLMGRVLW----------GSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICW 319
            :|::|:.:.|:...|.||          |:|             ::||||.||.:.:.::|.:||
Human   198 LPVLVLGLTYARTLRYLWRAVDPVAAGSGAR-------------RAKRKVTRMILIVAALFCLCW 249

  Fly   320 LPYHLFFIYAYHNNQVASTKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVG 384
            :|:|...:..:. .|...|:....:.:..:.::.:|:.|||::|..::|.||..|:.|    |.|
Human   250 MPHHALILCVWF-GQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTI----CAG 309

  Fly   385 L 385
            |
Human   310 L 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	92/308 (30%)
		TM helix 1	85..111	CDD:320512	8/25 (32%)
		TM helix 2	118..144	CDD:320512	12/28 (43%)
		TM helix 3	156..186	CDD:320512	13/29 (45%)
		TM helix 4	197..218	CDD:320512	7/20 (35%)
		TM helix 5	251..280	CDD:320512	6/28 (21%)
		TM helix 6	299..329	CDD:320512	11/29 (38%)
		TM helix 7	342..367	CDD:320512	5/24 (21%)
GALR2	NP_003848.1	7tmA_Gal2_Gal3_R	26..303	CDD:320225	92/308 (30%)
		TM helix 1	27..53	CDD:320225	8/25 (32%)
		TM helix 2	60..86	CDD:320225	11/27 (41%)
		TM helix 3	98..128	CDD:320225	13/29 (45%)
		TM helix 4	140..160	CDD:320225	7/19 (37%)
		TM helix 5	184..213	CDD:320225	7/36 (19%)
		TM helix 6	229..259	CDD:320225	11/29 (38%)
		TM helix 7	271..296	CDD:320225	5/24 (21%)