Protein Alignment TkR86C and KISS1R

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: XP_047295501.1
• Gene: KISS1R / 84634
• HGNCID: 4510
• Length: 459
• Species: Homo sapiens
• Alignment Length: 380
• Identity: 95/380 - (25%)
• Similarity: 154/380 - (40%)
• Gaps: 106/380 - (27%)

  Fly    86 WAI--IFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLN-- 146
            |.:  .|..:|.:.:.||.:|::::..|:.||||||:::.||:..|  ::.|.|...|..:|.
Human    43 WLVPLFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATD--VTFLLCCVPFTALLYPL 105

  Fly   147 SDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLK---RRTSRRKVRIILVLIWAL 208
            ..|..|...|...|::..|:|..:..||.|:|.||:...|.||:   |||.|..:.:.| .||..
Human   106 PGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSL-SIWVG 169

  Fly   209 SCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLIC 273
            |..:|||      ::..|..:...|..|...:|......:.|  .|||:.|   |.:|::....|
Human   170 SAAVSAP------VLALHRLSPGPRAYCSEAFPSRALERAFA--LYNLLAL---YLLPLLATCAC 223

  Fly   274 YSLM----GRV---------LWGSRSIGENTDR-------------------------------- 293
            |:.|    |||         ....|.:|..|.|
Human   224 YAAMLRHLGRVAVRPAPADSALQVRGVGGRTARLGGRGGTVVGGAGGGICAGRDSPRGPGGAVRG 288

  Fly   294 --------------------QMESMKS---KRKVVRMFIAIVSIFAICWLPYHLFFIY------- 328
                                |:.:.::   :.||.|:..|:|.:||.||.|..||.:.
Human   289 DELSRAPAFRLTTFTAPPQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAG 353

  Fly   329 AYHNNQVASTKYVQHMYLGFYW---LAMSNAMVNPLIYYWMNKRFRMYFQRIICC 380
            ::|....|:       |....|   ::.||:.:|||:|.::...||..|:|:..|
Human   354 SWHPRSYAA-------YALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPC 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	92/372 (25%)
		TM helix 1	85..111	CDD:320512	6/26 (23%)
		TM helix 2	118..144	CDD:320512	8/25 (32%)
		TM helix 3	156..186	CDD:320512	10/29 (34%)
		TM helix 4	197..218	CDD:320512	7/20 (35%)
		TM helix 5	251..280	CDD:320512	10/32 (31%)
		TM helix 6	299..329	CDD:320512	12/39 (31%)
		TM helix 7	342..367	CDD:320512	8/27 (30%)
KISS1R	XP_047295501.1	7tm_GPCRs	43..395	CDD:475119	92/372 (25%)
		TM helix 1	45..69	CDD:410628	5/23 (22%)
		TM helix 2	78..100	CDD:410628	7/23 (30%)
		TM helix 3	116..138	CDD:410628	6/21 (29%)
		TM helix 4	161..177	CDD:410628	7/22 (32%)
		TM helix 5	202..225	CDD:410628	8/27 (30%)
		TM helix 6	323..345	CDD:410628	10/21 (48%)
		TM helix 7	363..388	CDD:410628	8/24 (33%)