DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and C3ar1

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_114449.2	Gene:	C3ar1 / 84007	RGDID:	620537	Length:	472	Species:	Rattus norvegicus

Alignment Length:	439	Identity:	95/439 - (21%)
Similarity:	153/439 - (34%)	Gaps:	162/439 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 TRPYELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNC 137
            :||...|  |.....:|..|...:.:.|||:||| |.|.:..|||...:.|:|::||.|     |
  Rat    15 SRPLFKP--QDIASMVILSLTCLLGLPGNGLVLW-VAGVKMKRTVNTVWFLHLTLADFL-----C 71

  Fly   138 VFNFIF-----MLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPL--KRRTSR 195
            ..:..|     :|...||:|...|.:...|..:.:..|||.|.|||.||.:.:..|:  :...|.
  Rat    72 CLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSV 136

  Fly   196 RKVRIILVLIWALSCVLSAPCLLYSSIM------------------------------------- 223
            |....:...:|.::.|:..|..:|..::
  Rat   137 RTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFDSSRAYDYWDYMYNSHLPEINPPDN 201

  Fly   224 -TKH--------------------------------------------YYNGKSRTVCFMMWPDG 243
             |.|                                            :|.||..||.....|.|
  Rat   202 STGHVDDRTAPSSVPARDLWTATTALQSQTFHTSPEDPFSQDSASQQPHYGGKPPTVLIATIPGG 266

  Fly   244 --------------------RYPTSMA------------DY---------------AYNLIILVL 261
                                ..|:..|            ||               |..:..||:
  Rat   267 FPVEDHKSNTLNTGAFLSAHTEPSLTASSSPLYAHDFPDDYFDQLMYGNHAWTPQVAITISRLVV 331

  Fly   262 TYGIPMIVMLICYSLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFF 326
            .:.:|..:|:.||||:...:           |:....||:.|.:|:.:|:|::|.:||:|||:..
  Rat   332 GFLVPFFIMITCYSLIVFRM-----------RKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVG 385

  Fly   327 IYAYHNNQVASTKYV----QHMYLGFYWLAMSNAMVNPLIYYWMNKRFR 371
            |.....:|.::.:.|    .||.:.   ||.:|:..||.:|..:.|.||
  Rat   386 ILLVITDQESALREVVLPWDHMSIA---LASANSCFNPFLYALLGKDFR 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	90/420 (21%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	85/402 (21%)
C3ar1	NP_114449.2	7tm_GPCRs	24..434	CDD:421689	91/428 (21%)
		TM helix 1	25..51	CDD:410628	10/26 (38%)
		TM helix 2	57..82	CDD:410628	7/29 (24%)
		TM helix 3	95..125	CDD:410628	11/29 (38%)
		TM helix 4	137..157	CDD:410628	3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..251		0/18 (0%)
		TM helix 5	321..346	CDD:410628	7/24 (29%)
		TM helix 6	358..388	CDD:410628	13/29 (45%)
		TM helix 7	402..427	CDD:410628	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000