DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and GPR68

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_005268167.1	Gene:	GPR68 / 8111	HGNCID:	4519	Length:	375	Species:	Homo sapiens

Alignment Length:	314	Identity:	72/314 - (22%)
Similarity:	139/314 - (44%)	Gaps:	29/314 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 KTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLL-MSSLNCVFNFIFMLN 146
            :|:..:::..::.|....|.:.|:........|.....:|.||::|||. :.||.....:: :.:
Human    31 QTLAPVVYVTVLVVGFPANCLSLYFGYLQIKARNELGVYLCNLTVADLFYICSLPFWLQYV-LQH 94

  Fly   147 SDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLK---RRTSRRKVRIILVLIWAL 208
            .:|..|.:.|.:...:....:..||..|..||.|||:|:.||.:   .||.:..|. :.|:|||.
Human    95 DNWSHGDLSCQVCGILLYENIYISVGFLCCISVDRYLAVAHPFRFHQFRTLKAAVG-VSVVIWAK 158

  Fly   209 SCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLIC 273
            ..:.|...|::..::.    :.....|||     ..||......|.|....::.:..|:.::|..
Human   159 ELLTSIYFLMHEEVIE----DENQHRVCF-----EHYPIQAWQRAINYYRFLVGFLFPICLLLAS 214

  Fly   274 YSLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQVAST 338
            |..:.|.:  .||.|....|       |.::.|:.::.|.||..|:||||:..:  ..:...||.
Human   215 YQGILRAV--RRSHGTQKSR-------KDQIQRLVLSTVVIFLACFLPYHVLLL--VRSVWEASC 268

  Fly   339 KYVQHMYLGFYW---LAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHR 389
            .:.:.::..:::   |...|.:.:|::|.::::.......|:...|...||..|
Human   269 DFAKGVFNAYHFSLLLTSFNCVADPVLYCFVSETTHRDLARLRGACLAFLTCSR 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	66/290 (23%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	64/269 (24%)
GPR68	XP_005268167.1	7tmA_GPR68_OGR1	32..307	CDD:320489	67/296 (23%)
		TM helix 1	32..59	CDD:320489	4/26 (15%)
		TM helix 2	66..91	CDD:320489	8/24 (33%)
		TM helix 3	104..134	CDD:320489	10/29 (34%)
		TM helix 4	146..168	CDD:320489	6/22 (27%)
		TM helix 5	192..221	CDD:320489	5/28 (18%)
		TM helix 6	231..261	CDD:320489	11/38 (29%)
		TM helix 7	275..300	CDD:320489	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910