Protein Alignment TkR86C and gpr4l

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_001037961.1
• Gene: gpr4l / 733726
• XenbaseID: XB-GENE-5959820
• Length: 348
• Species: Xenopus tropicalis
• Alignment Length: 372
• Identity: 90/372 - (24%)
• Similarity: 177/372 - (47%)
• Gaps: 61/372 - (16%)

  Fly    82 QKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFML- 145
            :.|::.:|:.|:....:.||...:.|:..:.....:...:|.||..:||:         :||.|
 Frog    14 ETTLFPVIYSLVFLFGLVGNLAAIGIIVQNVKRGKILGVYLANLCASDLM---------YIFTLP 69

  Fly   146 -------NSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILV 203
                   ..||.||::.|.|..|..|..:.|::..|..|:.||::|.|.|.:.| |.|.::..|:
 Frog    70 VWIAYTAKDDWVFGALSCKIVGFFFNANLYTTIAFLSCIAMDRFVATVFPFQAR-SLRSMKTALI 133

  Fly   204 L---IWALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGI 265
            :   :|.:  :|...|:....  .:.:.:.::..:|:..:|...:   ||...|..|.:|  :.|
 Frog   134 ICAGVWLI--ILGTHCVFLGH--DELFLSSQNVQLCYEKYPMDEW---MAHINYFRIFVV--FLI 189

  Fly   266 PMIVMLICYSLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYH-LFFIYA 329
            |::::::.|..:|||:..|.|:         ..:.|||::.:.:.:::||.||:|||| :.||.:
 Frog   190 PLVLLIVSYCSVGRVVHQSTSL---------EKEQKRKIIGLLMTMMAIFIICYLPYHVVLFIRS 245

  Fly   330 YHNNQVAST----KYVQHMY-LGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVG--LTR 387
            |.:::...|    ..|:..| :.|...::|:|: :|.|..:::...:....:.|.....|  :.|
 Frog   246 YISDKDMCTCPLEVKVRPAYRISFCLTSLSSAL-DPFINIFVSDSIKQDLLKEIRALWAGFRILR 309

  Fly   388 HRFDSPKSRLTNKNSSNRHTRGGY-TVAHSLPNSS----PPTTQTLL 429
            |    |:..|..::|...    || ||.|::.|.:    |...:|:|
 Frog   310 H----PRDSLRRRSSKMM----GYNTVTHNIENDNLLIEPKKEETVL 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	74/306 (24%)
		TM helix 1	85..111	CDD:320512	5/25 (20%)
		TM helix 2	118..144	CDD:320512	6/25 (24%)
		TM helix 3	156..186	CDD:320512	10/29 (34%)
		TM helix 4	197..218	CDD:320512	4/23 (17%)
		TM helix 5	251..280	CDD:320512	7/28 (25%)
		TM helix 6	299..329	CDD:320512	13/30 (43%)
		TM helix 7	342..367	CDD:320512	6/25 (24%)
gpr4l	NP_001037961.1	7tmA_Proton-sensing_R	16..294	CDD:320288	74/306 (24%)
		TM helix 1	16..43	CDD:320288	6/26 (23%)
		TM helix 2	50..75	CDD:320288	8/33 (24%)
		TM helix 3	87..117	CDD:320288	10/29 (34%)
		TM helix 4	129..151	CDD:320288	4/23 (17%)
		TM helix 5	175..204	CDD:320288	9/30 (30%)
		TM helix 6	214..244	CDD:320288	12/29 (41%)
		TM helix 7	262..287	CDD:320288	6/25 (24%)