Protein Alignment TkR86C and TACR3

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_001050.1
• Gene: TACR3 / 6870
• HGNCID: 11528
• Length: 465
• Species: Homo sapiens
• Alignment Length: 467
• Identity: 153/467 - (32%)
• Similarity: 240/467 - (51%)
• Gaps: 80/467 - (17%)

  Fly    47 IIDNRDNLESINEAKDFLTECLFPSPTRPYELPWEQKT-----------IWAIIFGLMMFVAIAG 100
            ::|...||.|...|...  ....|:|::    ||...|           :|::.:|:::.||:.|
Human    44 LLDQAGNLSSSPSALGL--PVASPAPSQ----PWANLTNQFVQPSWRIALWSLAYGVVVAVAVLG 102

  Fly   101 NGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANV 165
            |.||:||:..|:.|||||||||:||:.:|..|::.|.:.|||:.|:|:|.||:.||...||....
Human   103 NLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPIT 167

  Fly   166 TVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVLIWALSCVLSAPCLLYSSIMTKHYYNG 230
            .|..|::::.||:.|||:||:.|||.|.|....:|::..||.|:.:|:.|..|||.....
Human   168 AVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVM----- 227

  Fly   231 KSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLMGRVLWGSRSIGENTDRQM 295
            ..||:||:.||:|    ....:.|::|:::|.|..|:::|.|.|:::|..|||....|:..|:..
Human   228 PGRTLCFVQWPEG----PKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYH 288

  Fly   296 ESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQVASTKYVQHMYLGFYWLAMSNAMVNP 360
            |.:|:|||||:|.|.:|..|||||||||::||......|:...||:|.:||..:|||||:.|.||
Human   289 EQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNP 353

  Fly   361 LIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPKSRLTNKNSSNRHTRGGYTVAHSLPNSSPPTT 425
            :||..:|||||..|:|....|           |..::::.:
Human   354 IIYCCLNKRFRAGFKRAFRWC-----------PFIKVSSYD------------------------ 383

  Fly   426 QTLLAVLAQTLTQPKPQTQLLLSHHSPHPTQPSAAETKSQWKRSTMETQIQQAPVTSSCREQRSA 490
                              :|.|.....||.:.|:..|.::.:..|:......|..|.|.|::| |
Human   384 ------------------ELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADTTRSSRKKR-A 429

  Fly   491 QQQQPPGSGTNR 502
            ..:.|..:|.:|
Human   430 TPRDPSFNGCSR 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	124/300 (41%)
		TM helix 1	85..111	CDD:320512	10/25 (40%)
		TM helix 2	118..144	CDD:320512	13/25 (52%)
		TM helix 3	156..186	CDD:320512	11/29 (38%)
		TM helix 4	197..218	CDD:320512	6/20 (30%)
		TM helix 5	251..280	CDD:320512	9/28 (32%)
		TM helix 6	299..329	CDD:320512	20/29 (69%)
		TM helix 7	342..367	CDD:320512	13/24 (54%)
TACR3	NP_001050.1	7tmA_NKR_NK3R	86..367	CDD:320669	123/289 (43%)
		TM helix 1	87..113	CDD:320669	10/25 (40%)
		TM helix 2	120..146	CDD:320669	13/25 (52%)
		TM helix 3	158..188	CDD:320669	11/29 (38%)
		TM helix 4	199..220	CDD:320669	6/20 (30%)
		TM helix 5	244..273	CDD:320669	9/28 (32%)
		TM helix 6	292..322	CDD:320669	20/29 (69%)
		TM helix 7	335..360	CDD:320669	13/24 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..465		9/28 (32%)