Protein Alignment TkR86C and TACR2

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_001048.2
• Gene: TACR2 / 6865
• HGNCID: 11527
• Length: 398
• Species: Homo sapiens
• Alignment Length: 343
• Identity: 123/343 - (35%)
• Similarity: 199/343 - (58%)
• Gaps: 24/343 - (6%)

  Fly    76 YELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFN 140
            :.:|..|..:||..:..::.||:.||.||:||:..||.||||||||::||::|||.|::.|..||
Human    26 FSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFN 90

  Fly   141 FIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVLI 205
            |::..::.|.||..:|...|......:..|::::.||:.|||:|||||.:.|.|....:.::..|
Human    91 FVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGI 155

  Fly   206 WALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVM 270
            |.::..|::|...||::..     .:..|.|.:.||:.....::  ..|:|:::.|.|.:|:.||
Human   156 WLVALALASPQCFYSTVTM-----DQGATKCVVAWPEDSGGKTL--LLYHLVVIALIYFLPLAVM 213

  Fly   271 LICYSLMGRVLW-----GSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAY 330
            .:.||::|..||     |.::.|.|. |.:::||   |.|:..:.:|..||||||||||:||...
Human   214 FVAYSVIGLTLWRRAVPGHQAHGANL-RHLQAMK---KFVKTMVLVVLTFAICWLPYHLYFILGS 274

  Fly   331 HNNQVASTKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHRFD---- 391
            ....:...|::|.:||..:|||||:.|.||:||..:|.|||..| |:...||..:|..:.|
Human   275 FQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF-RLAFRCCPWVTPTKEDKLEL 338

  Fly   392 SPKSRLTNKNSSNR-HTR 408
            :|.:.|:.:  .|| ||:
Human   339 TPTTSLSTR--VNRCHTK 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	109/294 (37%)
		TM helix 1	85..111	CDD:320512	10/25 (40%)
		TM helix 2	118..144	CDD:320512	14/25 (56%)
		TM helix 3	156..186	CDD:320512	9/29 (31%)
		TM helix 4	197..218	CDD:320512	4/20 (20%)
		TM helix 5	251..280	CDD:320512	10/28 (36%)
		TM helix 6	299..329	CDD:320512	16/29 (55%)
		TM helix 7	342..367	CDD:320512	13/24 (54%)
TACR2	NP_001048.2	7tmA_SKR_NK2R	34..318	CDD:320670	109/294 (37%)
		TM helix 1	35..61	CDD:320670	10/25 (40%)
		TM helix 2	68..94	CDD:320670	14/25 (56%)
		TM helix 3	106..136	CDD:320670	9/29 (31%)
		TM helix 4	147..168	CDD:320670	4/20 (20%)
		TM helix 5	194..223	CDD:320670	10/30 (33%)
		TM helix 6	243..273	CDD:320670	17/32 (53%)
		TM helix 7	286..311	CDD:320670	13/24 (54%)