DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and P2ry4

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_113868.1	Gene:	P2ry4 / 63843	RGDID:	61798	Length:	361	Species:	Rattus norvegicus

Alignment Length:	363	Identity:	88/363 - (24%)
Similarity:	161/363 - (44%)	Gaps:	61/363 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 INEAKDFLTECLFPSPT------RPYE------LPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVT 109
            :..|:..|...|.|||:      |..|      ||..    :|::|.|    .:|.|...||:..
  Rat     1 MTSAESLLFTSLGPSPSSGDGDCRFNEEFKFILLPMS----YAVVFVL----GLALNAPTLWLFL 57

  Fly   110 GHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTL 174
            ........|..::.:|:::|.|.........:.:...:.||||:..|....|:....:..||..|
  Rat    58 FRLRPWDATATYMFHLALSDTLYVLSLPTLVYYYAARNHWPFGTGLCKFVRFLFYWNLYCSVLFL 122

  Fly   175 VAISFDRYIAIVHPLKR-RTSRRKVRIILVL-IWALSCVLSAPCLLYSSIMTKHYYNGKSRTVCF 237
            ..||..||:.|.|||:. |..|.:...:|.| :|    ::.|.||:.:........||.:
  Rat   123 TCISVHRYLGICHPLRAIRWGRPRFASLLCLGVW----LVVAGCLVPNLFFVTTNANGTT----- 178

  Fly   238 MMWPDGRYPTSMADYAY-NLIILVLTYGIPMIVMLICYSLMGRVLW----GSRSIGENTDRQMES 297
            ::..|...|.....|.| :..::||.:|:|.::.|:||.||.|.|:    |:   |:::.|
  Rat   179 ILCHDTTLPEEFDHYVYFSSAVMVLLFGLPFLITLVCYGLMARRLYRPLPGA---GQSSSR---- 236

  Fly   298 MKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQVASTKYVQHMYLGFYW----LAMSNAMV 358
            ::|.|.:.    .::::||:|::|:|:.....|....:.:..:|.::....|.    ||.:|:.:
  Rat   237 LRSLRTIA----VVLTVFAVCFVPFHITRTIYYQARLLQADCHVLNIVNVVYKVTRPLASANSCL 297

  Fly   359 NPLIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPKSR 396
            :|::|.:...::|...|::    |.|      ..||.|
  Rat   298 DPVLYLFTGDKYRNQLQQL----CRG------SKPKPR 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	70/294 (24%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	66/273 (24%)
P2ry4	NP_113868.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		6/18 (33%)
		7tmA_P2Y4	32..313	CDD:320496	74/308 (24%)
		TM helix 1	34..58	CDD:320496	9/31 (29%)
		TM helix 2	67..88	CDD:320496	3/20 (15%)
		TM helix 3	105..127	CDD:320496	5/21 (24%)
		TM helix 4	150..166	CDD:320496	6/19 (32%)
		TM helix 5	194..217	CDD:320496	7/22 (32%)
		TM helix 6	240..262	CDD:320496	6/25 (24%)
		TM helix 7	281..306	CDD:320496	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000