DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and p2ry4

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001025633.1	Gene:	p2ry4 / 595021	XenbaseID:	XB-GENE-943446	Length:	543	Species:	Xenopus tropicalis

Alignment Length:	471	Identity:	108/471 - (22%)
Similarity:	187/471 - (39%)	Gaps:	98/471 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VNTTLLGSLNRTEVVSLLSSIIDNRDNLESINEAKDFLTECLFPSPTRPYELPWEQKTIWAIIFG 91
            :..||..||..|  :.|..::.:|.::....||...||   |.|                 |.:.
Frog     5 IMATLHPSLLTT--LPLPKNLTNNTEDSCVFNEGFKFL---LLP-----------------ISYS 47

  Fly    92 LMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYC 156
            .:..|.:..|...:||..........|..::.||:::|.|.........:.:...::||||...|
Frog    48 GVFMVGLPLNITAIWIFIAKMRPWNPTTVYMFNLALSDTLYVLSLPTLVYYYADQNNWPFGVALC 112

  Fly   157 TINNFVANVTVSTSVFTLVAISFDRYIAIVHPLK--RRTSRRKVRIILVLIWALSCVLSAPCLLY 219
            .|..|:....:.:|:..|..||..||..:.||:.  |..:.:...:|..|:|....:...|.|::
Frog   113 KIVRFLFYANLYSSILFLTCISVHRYRGVCHPITTLRCMNAKHAHVICALVWLSVMLCLVPNLMF 177

  Fly   220 SSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYA-YNLIILVLTYGIPMIVMLICYSLMGRVLWG 283
            .::..|  .||   |:|.    |...|.....|. |:..|:.|.:|||.:::..||.||.|.|..
Frog   178 VTVSPK--VNG---TICH----DTTLPEEFDKYVEYSTGIMCLLFGIPCLIIACCYGLMARELMK 233

  Fly   284 SRSIGENTDRQMESMKS-KRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQVASTKYVQHMYLG 347
            ....|.:     :::.| |::.::..:.::..||||::|:|:.....|:...:....|..:: :.
Frog   234 PLVNGNH-----QTLPSYKKRSIKTIVIVMIAFAICFMPFHITRTLYYYARLLGVNCYALNV-IN 292

  Fly   348 FYW-----LAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPKSRLTNKNSSNRHT 407
            |.:     ||.:|:.::|::|:..|.|:|   :|:|                  .|.:.||..|.
Frog   293 FTYKITRPLASANSCIDPILYFLANDRYR---RRLI------------------RTVRRSSVHHR 336

  Fly   408 RGGYTVAHSLPNSSPPTTQTLLAVLAQTLTQPKPQTQLLLSHHSPHPTQPSAAETKSQWKRSTME 472
            |..:| .|..|:..|....|         |.|.|..              ||.||:|..:....|
Frog   337 RCMHT-NHPGPHPEPEPHMT---------TGPLPVV--------------SAEETQSNGRMVRDE 377

  Fly   473 TQIQQAPVTSSCREQR 488
            .:       ...||.|
Frog   378 NE-------EGAREHR 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	70/292 (24%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	65/271 (24%)
p2ry4	NP_001025633.1	7tmA_P2Y4	40..320	CDD:320496	72/314 (23%)
		TM helix 1	40..67	CDD:320496	8/46 (17%)
		TM helix 2	74..99	CDD:320496	5/24 (21%)
		TM helix 3	112..142	CDD:320496	9/29 (31%)
		TM helix 4	154..176	CDD:320496	4/21 (19%)
		TM helix 5	201..230	CDD:320496	11/28 (39%)
		TM helix 6	245..275	CDD:320496	8/29 (28%)
		TM helix 7	292..317	CDD:320496	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910