DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and P2ry4

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_065646.1	Gene:	P2ry4 / 57385	MGIID:	1926594	Length:	361	Species:	Mus musculus

Alignment Length:	360	Identity:	90/360 - (25%)
Similarity:	162/360 - (45%)	Gaps:	51/360 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 INEAKDFLTECLFPSPTR---PYELPWEQKTI-----WAIIFGLMMFVAIAGNGIVLWIVTGHRS 113
            :..|...|...|.|||:.   ..:...|.|.|     :|::|.|    .:|.|...||:......
Mouse     1 MTSADSLLFTSLGPSPSSGDGDCKFNEEFKFILLPLSYAVVFVL----GLALNAPTLWLFLFRLR 61

  Fly   114 MRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAIS 178
            ....|..::.:|:::|.|.........:.:...:.||||:.:|....|:....:..||..|..||
Mouse    62 PWDATATYMFHLALSDTLYVLSLPTLVYYYAARNHWPFGTGFCKFVRFLFYWNLYCSVLFLTCIS 126

  Fly   179 FDRYIAIVHPLKR-RTSRRKVRIILVL-IWALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWP 241
            ..||:.|.|||:. |..|.:...:|.| :|    ::.|.||:.:........||.:     ::..
Mouse   127 VHRYMGICHPLRAIRWGRPRFAGLLCLGVW----LVVAGCLVPNLFFVTTNANGTT-----ILCH 182

  Fly   242 DGRYPTSMADYAY-NLIILVLTYGIPMIVMLICYSLMGRVLWGSRSI---GENTDRQMESMKSKR 302
            |...|.....|.| :..|:||.:|.|.::.|:||.||.|.|:  |.:   |:::.|    ::|.|
Mouse   183 DTTLPEEFDHYVYFSSTIMVLLFGFPFLITLVCYGLMARRLY--RPLPGAGQSSSR----LRSLR 241

  Fly   303 KVVRMFIAIVSIFAICWLPYH----LFFIYAYHNNQVASTKYVQHMYLGFYWLAMSNAMVNPLIY 363
            .:.    .::::||:|::|:|    ::::....|.:......|..:|.....||.:|:.::|::|
Mouse   242 TIA----VVLTVFAVCFVPFHITRTIYYLARLLNAECRVLNIVNVVYKVTRPLASANSCLDPVLY 302

  Fly   364 YWMNKRFRMYFQRIICCCCVGLTRHRFDSPKSRLT 398
            .:...::|...|::    |.|.|      ||.|.|
Mouse   303 LFTGDKYRNQLQQL----CRGST------PKRRTT 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	71/293 (24%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	67/272 (25%)
P2ry4	NP_065646.1	7tmA_P2Y4	32..313	CDD:320496	74/303 (24%)
		TM helix 1	32..59	CDD:320496	8/30 (27%)
		TM helix 2	66..91	CDD:320496	4/24 (17%)
		TM helix 3	104..134	CDD:320496	9/29 (31%)
		TM helix 4	146..168	CDD:320496	6/25 (24%)
		TM helix 5	193..222	CDD:320496	12/28 (43%)
		TM helix 6	234..264	CDD:320496	8/37 (22%)
		TM helix 7	281..306	CDD:320496	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000