DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and SUCNR1

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_149039.2	Gene:	SUCNR1 / 56670	HGNCID:	4542	Length:	334	Species:	Homo sapiens

Alignment Length:	330	Identity:	85/330 - (25%)
Similarity:	146/330 - (44%)	Gaps:	54/330 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 QKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIF--M 144
            :|...:|.:|:...|.:.||.||::...........:|.:|.|||::||   :..|....:.  .
Human    22 EKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDL---AFLCTLPMLIRSY 83

  Fly   145 LNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILV--LIWA 207
            .|.:|.:|.:.|..|.:|.:..:.||:..|..||.|||:.|.:|.:....::|...||:  .||.
Human    84 ANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWV 148

  Fly   208 LSCVLSAPCL-LYSSIMTKHYYNGKSRTVC--FMMWPDGRYPTSMADYAYNLIILVLTYGIPMIV 269
            |..:...|.| |.:.::|.   ||   |.|  |....|..|     :..|::.:.:|.:.||:.|
Human   149 LVTLELLPILPLINPVITD---NG---TTCNDFASSGDPNY-----NLIYSMCLTLLGFLIPLFV 202

  Fly   270 MLICYSLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQ 334
            |...|..:...|       :..:||:.:.....|.:.:.|..|.||::.:.|||:.     .|.:
Human   203 MCFFYYKIALFL-------KQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVM-----RNVR 255

  Fly   335 VAS-----TKY------VQHMYLGFYWLAMSNAMVNPLIYYWMNKRFR-MYFQRIICCCCVGLTR 387
            :||     .:|      :...|:....||..|:::||:.|:.:...|| |...::         |
Human   256 IASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQL---------R 311

  Fly   388 HRFDS 392
            |.|.|
Human   312 HNFKS 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	78/302 (26%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	73/280 (26%)
SUCNR1	NP_149039.2	7tmA_SUCNR1_GPR91	24..306	CDD:320500	79/307 (26%)
		TM helix 1	24..51	CDD:320500	7/26 (27%)
		TM helix 2	58..83	CDD:320500	8/27 (30%)
		TM helix 3	95..125	CDD:320500	11/29 (38%)
		TM helix 4	137..159	CDD:320500	6/21 (29%)
		TM helix 5	184..213	CDD:320500	7/28 (25%)
		TM helix 6	225..255	CDD:320500	9/34 (26%)
		TM helix 7	274..299	CDD:320500	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910