Protein Alignment TkR86C and hcrtr2

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_001073337.1
• Gene: hcrtr2 / 561260
• ZFINID: ZDB-GENE-070228-3
• Length: 424
• Species: Danio rerio
• Alignment Length: 429
• Identity: 125/429 - (29%)
• Similarity: 208/429 - (48%)
• Gaps: 68/429 - (15%)

  Fly    44 LSSIIDNRDNLESINEAKDFL----TECLFPSPTRPYELPWEQKTIWAIIFG--LMMFVAIAGNG 102
            |:|..|...:..:.||..:.|    .|.|.|   :.||        |.:|.|  |:..|::.||.
Zfish    20 LNSSADTISHSHAENEDDELLKYIWREYLHP---KQYE--------WVLIAGYILVFLVSLVGNT 73

  Fly   103 IVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCV-FNFIFMLNSDWPFGSIYCTINNFVANVT 166
            :|.:.|..:..||||||||::|||.||:|: ::.|: .:.:..:...|.||...|.|..::..::
Zfish    74 LVCFAVWKNHHMRTVTNYFIVNLSFADILV-TITCLPASLVVDITETWFFGQTLCKILPYLQTIS 137

  Fly   167 VSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVLIWALSCVLSAP--CLLYSSIMTKHYYN 229
            ||.||.||..|:.||:.||.||||.:::.::.|..:||||.:||::..|  .::.||.:.....|
Zfish   138 VSVSVLTLSCIAQDRWYAICHPLKFKSTAKRARKSIVLIWLVSCIMMIPQAVVMESSSLMPELTN 202

  Fly   230 GKSR-TVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLMGRVLW-----GSRSI- 287
            ..|. |||...|||..||.     .|:....::||..|:.:|::.|..:...||     ||.|:
Zfish   203 KTSLFTVCDEQWPDEIYPK-----VYHTCFFIVTYFAPLCLMVLAYIQICHKLWCQQIPGSSSVL 262

  Fly   288 ----------------GEN-------TDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIY- 328
                            ||:       ...:.:.:|::||..||.:.::.:||:|:||..:..|.
Zfish   263 QRQWKSLQCSAHAVGSGESVKVRTSTVSAEAKQVKARRKTARMLMVVLFVFALCYLPISILNIMK 327

  Fly   329 ----AYHNNQVASTKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHR 389
                |:.|.....|.|....:  .:||..:|:..||:||.:::.:||..|:....|.|.|    |
Zfish   328 RVFGAFKNTGNRETVYAWFTF--SHWLIYANSAANPIIYNFLSGKFREEFKAAFICQCSG----R 386

  Fly   390 FDSPKSRLTNKNSSNRHTRGGYTVAHSLPNSSPPTTQTL 428
            .::.|.|...:.|::.. :...|..::|.|.|..:.|.:
Zfish   387 GETHKQRARGRTSTDSR-KSLSTQVNNLDNISRISDQAV 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	101/329 (31%)
		TM helix 1	85..111	CDD:320512	9/27 (33%)
		TM helix 2	118..144	CDD:320512	11/26 (42%)
		TM helix 3	156..186	CDD:320512	12/29 (41%)
		TM helix 4	197..218	CDD:320512	8/22 (36%)
		TM helix 5	251..280	CDD:320512	6/28 (21%)
		TM helix 6	299..329	CDD:320512	11/34 (32%)
		TM helix 7	342..367	CDD:320512	7/24 (29%)
hcrtr2	NP_001073337.1	7tmA_OXR	55..375	CDD:320336	101/327 (31%)
		TM helix 1	56..82	CDD:320336	8/25 (32%)
		TM helix 2	89..115	CDD:320336	11/26 (42%)
		TM helix 3	127..157	CDD:320336	12/29 (41%)
		TM helix 4	168..189	CDD:320336	8/20 (40%)
		TM helix 5	220..249	CDD:320336	7/33 (21%)
		TM helix 6	297..327	CDD:320336	11/29 (38%)
		TM helix 7	343..368	CDD:320336	8/26 (31%)
		Orexin_rec2	390..>424	CDD:427531	8/34 (24%)