Protein Alignment TkR86C and NPY4R

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_005963.4
• Gene: NPY4R / 5540
• HGNCID: 9329
• Length: 375
• Species: Homo sapiens
• Alignment Length: 346
• Identity: 85/346 - (24%)
• Similarity: 164/346 - (47%)
• Gaps: 39/346 - (11%)

  Fly    64 LTECLFP-SP-----TRPYELPWE-----QKTIWAIIF-----GLMMFVAIAGNGIVLWIVTGHR 112
            |...|.| ||     ::|...|:.     |.::..::|     .:...|.:.||..::.:....:
Human     6 LLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVTVRQK 70

  Fly   113 SMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAI 177
            ....|||..:.||:.:|.||..|......::.:...|.||...|.::.|:..::|:.|:.:||.:
Human    71 EKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLV 135

  Fly   178 SFDRYIAIVHPLKRRTSRRKVRIILVLIWALSCVLSAPCLLYSSIMTKHYYNGKS--------RT 234
            :.:|:..|::|...:.|..:..:.:||||.::||||.| .|.:||:...::...|        :.
Human   136 ALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLP-FLANSILENVFHKNHSKALEFLADKV 199

  Fly   235 VCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLMGRVLWGSRSIGENTDRQMESMK 299
            ||...||...:.|     .|...:|:..|.:|:..:|:||:.:.|.|.....:.......:.:..
Human   200 VCTESWPLAHHRT-----IYTTFLLLFQYCLPLGFILVCYARIYRCLQRQGRVFHKGTYSLRAGH 259

  Fly   300 SKRKVVRMFIAIVSIFAICWLPYHLF-FIYAYHNNQVASTKYVQH---MYLGFYWLAMSNAMVNP 360
            .|:..|.:.:.:|: ||:.|||.|:| .:..:|:..:.    :.|   ::|..:.|||::..|||
Human   260 MKQVNVVLVVMVVA-FAVLWLPLHVFNSLEDWHHEAIP----ICHGNLIFLVCHLLAMASTCVNP 319

  Fly   361 LIYYWMNKRFRMYFQRIICCC 381
            .||.::|..|:...:.::..|
Human   320 FIYGFLNTNFKKEIKALVLTC 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	76/306 (25%)
		TM helix 1	85..111	CDD:320512	4/30 (13%)
		TM helix 2	118..144	CDD:320512	8/25 (32%)
		TM helix 3	156..186	CDD:320512	7/29 (24%)
		TM helix 4	197..218	CDD:320512	9/20 (45%)
		TM helix 5	251..280	CDD:320512	7/28 (25%)
		TM helix 6	299..329	CDD:320512	10/30 (33%)
		TM helix 7	342..367	CDD:320512	10/27 (37%)
NPY4R	NP_005963.4	7tmA_NPY4R	42..333	CDD:320519	76/301 (25%)
		TM helix 1	43..69	CDD:320519	4/25 (16%)
		TM helix 2	76..101	CDD:320519	8/24 (33%)
		TM helix 3	114..144	CDD:320519	7/29 (24%)
		TM helix 4	155..176	CDD:320519	9/21 (43%)
		TM helix 5	211..240	CDD:320519	8/33 (24%)
		TM helix 6	258..288	CDD:320519	10/30 (33%)
		TM helix 7	301..326	CDD:320519	9/24 (38%)