Protein Alignment TkR86C and OPRM1

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_001138751.1
• Gene: OPRM1 / 4988
• HGNCID: 8156
• Length: 493
• Species: Homo sapiens
• Alignment Length: 371
• Identity: 97/371 - (26%)
• Similarity: 177/371 - (47%)
• Gaps: 57/371 - (15%)

  Fly    84 TIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSD 148
            ||.| ::.::..|.:.||.:|::::..:..|:|.||.::.||::||.|.:| ...|..:..|...
Human   165 TIMA-LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGT 227

  Fly   149 WPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSR--RKVRIILVLIWALSCV 211
            ||||:|.|.|...:....:.||:|||..:|.|||||:.||:|....|  |..:||.|..|.||..
Human   228 WPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSA 292

  Fly   212 LSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSL 276
            :..|.:..::  ||:.......|:.|      .:||...:....:.:.:..:.:|::::.:||.|
Human   293 IGLPVMFMAT--TKYRQGSIDCTLTF------SHPTWYWENLLKICVFIFAFIMPVLIITVCYGL 349

  Fly   277 M------GRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQV 335
            |      .|:|.||:          |..::.|::.||.:.:|::|.:||.|.|::.|..
Human   350 MILRLKSVRMLSGSK----------EKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIK------ 398

  Fly   336 ASTKYVQHMYLGFYW-----LAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPKS 395
            |.....:..:....|     |..:|:.:||::|.::::.|:..|:..    |:        ...|
Human   399 ALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREF----CI--------PTSS 451

  Fly   396 RLTNKNSS--NRHTRGGYTVAHSLPNSSPPTTQTLLAVLAQTLTQP 439
            .:..:||:  .::||...:.|    |:...|...|..:.|:|...|
Human   452 NIEQQNSTRIRQNTRDHPSTA----NTVDRTNHQLENLEAETAPLP 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	83/302 (27%)
		TM helix 1	85..111	CDD:320512	6/25 (24%)
		TM helix 2	118..144	CDD:320512	9/25 (36%)
		TM helix 3	156..186	CDD:320512	13/29 (45%)
		TM helix 4	197..218	CDD:320512	7/20 (35%)
		TM helix 5	251..280	CDD:320512	5/34 (15%)
		TM helix 6	299..329	CDD:320512	10/29 (34%)
		TM helix 7	342..367	CDD:320512	6/29 (21%)
OPRM1	NP_001138751.1	7tmA_Mu_opioid_R	164..442	CDD:320218	83/302 (27%)
		TM helix 1	165..191	CDD:320218	7/26 (27%)
		TM helix 2	198..224	CDD:320218	9/26 (35%)
		TM helix 3	235..265	CDD:320218	13/29 (45%)
		TM helix 4	277..299	CDD:320218	8/21 (38%)
		TM helix 5	324..353	CDD:320218	5/28 (18%)
		TM helix 6	368..398	CDD:320218	10/29 (34%)
		TM helix 7	410..435	CDD:320218	6/24 (25%)