Protein Alignment TkR86C and OPRK1

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_001305426.1
• Gene: OPRK1 / 4986
• HGNCID: 8154
• Length: 409
• Species: Homo sapiens
• Alignment Length: 340
• Identity: 89/340 - (26%)
• Similarity: 168/340 - (49%)
• Gaps: 43/340 - (12%)

  Fly    71 SPTRPYELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSL 135
            ||..|        .|...::.::..|.:.||.:|::::..:..|:|.||.::.||::||.|:::.
Human    55 SPAIP--------VIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTT 111

  Fly   136 NCVFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRR--KV 198
            ....:.::::|| ||||.:.|.|...:....:.||:|||..:|.|||||:.||:|....|.  |.
Human   112 MPFQSTVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKA 175

  Fly   199 RIILVLIWALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTY 263
            :||.:.||.||..:....::......:   .......|.:.:||..|  |..|....:.:.:..:
Human   176 KIINICIWLLSSSVGISAIVLGGTKVR---EDVDVIECSLQFPDDDY--SWWDLFMKICVFIFAF 235

  Fly   264 GIPMIVMLICYSLM------GRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPY 322
            .||::::::||:||      .|:|.|||          |..::.|::.|:.:.:|::|.:||.|.
Human   236 VIPVLIIIVCYTLMILRLKSVRLLSGSR----------EKDRNLRRITRLVLVVVAVFVVCWTPI 290

  Fly   323 HLFFIYAYHNNQVASTKYVQHMYLGFYW---LAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVG 384
            |:|.:.    ..:.||.:.......:|:   |..:|:.:||::|.::::.|:..|:..    |..
Human   291 HIFILV----EALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDF----CFP 347

  Fly   385 LTRHRFDSPKSRLTN 399
            |.........||:.|
Human   348 LKMRMERQSTSRVRN 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	80/300 (27%)
		TM helix 1	85..111	CDD:320512	5/25 (20%)
		TM helix 2	118..144	CDD:320512	7/25 (28%)
		TM helix 3	156..186	CDD:320512	13/29 (45%)
		TM helix 4	197..218	CDD:320512	7/20 (35%)
		TM helix 5	251..280	CDD:320512	7/34 (21%)
		TM helix 6	299..329	CDD:320512	9/29 (31%)
		TM helix 7	342..367	CDD:320512	6/27 (22%)
OPRK1	NP_001305426.1	7tmA_Kappa_opioid_R	60..341	CDD:320219	80/300 (27%)
		TM helix 1	61..87	CDD:320219	5/25 (20%)
		TM helix 2	94..120	CDD:320219	7/25 (28%)
		TM helix 3	131..161	CDD:320219	13/29 (45%)
		TM helix 4	173..195	CDD:320219	7/21 (33%)
		TM helix 5	223..252	CDD:320219	7/28 (25%)
		TM helix 6	267..297	CDD:320219	9/33 (27%)
		TM helix 7	309..334	CDD:320219	6/24 (25%)