Protein Alignment TkR86C and NPY5R

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: XP_011530317.1
• Gene: NPY5R / 4889
• HGNCID: 7958
• Length: 452
• Species: Homo sapiens
• Alignment Length: 426
• Identity: 80/426 - (18%)
• Similarity: 155/426 - (36%)
• Gaps: 123/426 - (28%)

  Fly    73 TRPYELP-WEQ-----KTIWAIIFGLMMFVAI---AGNGIVLWIVTGHRSMRTVTNYFLLNLSIA 128
            ||..:.| |:.     ..:...:.||..||::   .||.::|..:...|:.:|..|:.:.||:.:
Human    29 TRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFS 93

  Fly   129 DLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRT 193
            |:|:......|....:|...|.||.:.|.|..|:..|:|..|...|::|:..||..|.||:....
Human    94 DILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNL 158

  Fly   194 SRRKVRIILVLIWALSCVLSAPCLLYSSIMTKHYYNG----KSRTVCFMMWPDGRYPTSMADYAY 254
            :......::..:|.|...:.:|..::.|::......|    .||.:|...||...|     ..|:
Human   159 TANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSY-----RIAF 218

  Fly   255 NLIILVLTYGIPMIVMLICYS--------------------------------------LMGRVL 281
            .:.:|::.|.:|::.:.:.::                                      |.|...
Human   219 TISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHK 283

  Fly   282 WG------------------------------SRSIGEN-------------------------- 290
            |.                              ||.:.||
Human   284 WSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKP 348

  Fly   291 -TDRQMESMKSKRKVVRM----------FIAIVSIFAICWLPYHLFFIYAYHNNQVASTKYVQHM 344
             .:..:..::.||.|.|:          ...::.:||:.|:|.|||.:....|:.:.|.::.:.:
Human   349 EENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLV 413

  Fly   345 YLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICC 380
            |...:.|.|.:..:||::|.::|...:.....:|.|
Human   414 YCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHC 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	74/401 (18%)
		TM helix 1	85..111	CDD:320512	7/28 (25%)
		TM helix 2	118..144	CDD:320512	6/25 (24%)
		TM helix 3	156..186	CDD:320512	10/29 (34%)
		TM helix 4	197..218	CDD:320512	3/20 (15%)
		TM helix 5	251..280	CDD:320512	6/66 (9%)
		TM helix 6	299..329	CDD:320512	11/39 (28%)
		TM helix 7	342..367	CDD:320512	6/24 (25%)
NPY5R	XP_011530317.1	7tmA_NPY5R	49..443	CDD:320520	74/398 (19%)
		TM helix 1	50..76	CDD:320520	7/25 (28%)
		TM helix 2	83..108	CDD:320520	6/24 (25%)
		TM helix 3	121..151	CDD:320520	10/29 (34%)
		TM helix 4	162..183	CDD:320520	3/20 (15%)
		TM helix 5	215..244	CDD:320520	4/28 (14%)
		TM helix 6	368..398	CDD:320520	7/29 (24%)
		TM helix 7	411..436	CDD:320520	6/24 (25%)