Protein Alignment TkR86C and NMBR

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_002502.2
• Gene: NMBR / 4829
• HGNCID: 7843
• Length: 390
• Species: Homo sapiens
• Alignment Length: 410
• Identity: 110/410 - (26%)
• Similarity: 191/410 - (46%)
• Gaps: 73/410 - (17%)

  Fly    46 SIIDNRDNLESINEA--KDFL-------TE----CLFPSPTRPYELPWEQKTIWAIIFGLMMFVA 97
            |:....:...|:.|.  :|||       ||    |:.||                 ::.|::.|.
Human    10 SVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPS-----------------LYLLIITVG 57

  Fly    98 IAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCV----FNFIFMLNSDWPFGSIYCTI 158
            :.||.:::.|...:.:||:|.|.|:.||:..|||: .|.||    ..:.|   .:|.||.:.|.:
Human    58 LLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLL-LLTCVPVDASRYFF---DEWMFGKVGCKL 118

  Fly   159 NNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVR--IILVLIWALSCVLSAPCLLYSS 221
            ...:...:|..|||||.|:|.|||.|||:|:..:||...:|  :..:.||.:|.:|:.|..::|.
Human   119 IPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSE 183

  Fly   222 IMTKHYYNGKSRTVCFMMWPDGRYPTS--MADYAYNLIILVLTYGIPMIVMLICYSLMGRVLWGS 284
            :......:..|.|.|.      .||.:  :....::::|.::.:.||:.::.|.|..:.:.|..|
Human   184 VARISSLDNSSFTACI------PYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKS 242

  Fly   285 R-----SIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIY-AYHNNQVASTKYVQH 343
            .     ...|:|.:|||:.|...|:|.:|   |..|..||.|.|:.::| :::.|::..:  :.|
Human   243 AHNLPGEYNEHTKKQMETRKRLAKIVLVF---VGCFIFCWFPNHILYMYRSFNYNEIDPS--LGH 302

  Fly   344 MYLGFY--WLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGL-------TRHRFDSPKSRLTN 399
            |.:...  .|:..|:.|||...|.:::.||.:|...:||   |.       |.:...|...|:|:
Human   303 MIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCC---GRKSYQERGTSYLLSSSAVRMTS 364

  Fly   400 --KNSSNRHTRGGYTVAHSL 417
              .|:.|..|.......||:
Human   365 LKSNAKNMVTNSVLLNGHSM 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	86/305 (28%)
		TM helix 1	85..111	CDD:320512	5/25 (20%)
		TM helix 2	118..144	CDD:320512	10/29 (34%)
		TM helix 3	156..186	CDD:320512	13/29 (45%)
		TM helix 4	197..218	CDD:320512	6/22 (27%)
		TM helix 5	251..280	CDD:320512	5/28 (18%)
		TM helix 6	299..329	CDD:320512	11/30 (37%)
		TM helix 7	342..367	CDD:320512	8/26 (31%)
NMBR	NP_002502.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		2/11 (18%)
		7tmA_NMBR	44..335	CDD:320253	89/322 (28%)
		TM helix 1	45..71	CDD:320253	7/42 (17%)
		TM helix 2	78..104	CDD:320253	10/26 (38%)
		TM helix 3	116..146	CDD:320253	13/29 (45%)
		TM helix 4	158..178	CDD:320253	5/19 (26%)
		TM helix 5	209..234	CDD:320253	5/24 (21%)
		TM helix 6	259..289	CDD:320253	11/32 (34%)
		TM helix 7	303..328	CDD:320253	7/24 (29%)