DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and TkR99D

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001263092.1	Gene:	TkR99D / 43551	FlyBaseID:	FBgn0004622	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	180/494 - (36%)
Similarity:	264/494 - (53%)	Gaps:	85/494 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SLNRTEVVSLLSSIIDNRDNLESINEAKDFLTECLFPSPTRPYE--LPWEQKTIWAIIFGLMMFV 96
            |.|.::.:|         .:|.::.:.:|...:......|..:.  :||.::.:|:|:||.|:.|
  Fly    59 SFNHSQTLS---------TDLPAVGDVEDAAEDAAASMETGSFAFVVPWWRQVLWSILFGGMVIV 114

  Fly    97 AIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNF 161
            |..||.||:|||...:.||||||||::||||||.::||||..||:.:||:||||||..||.::.|
  Fly   115 ATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFNYYYMLDSDWPFGEFYCKLSQF 179

  Fly   162 VANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVLIWALSCVLSAPCLLYSSIMTKH 226
            :|.:::..|||||:|||.|||:||:.||:.|.|:|....|..:||..|.::|.|.::........
  Fly   180 IAMLSICASVFTLMAISIDRYVAIIRPLQPRMSKRCNLAIAAVIWLASTLISCPMMIIYRTEEVP 244

  Fly   227 YYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLMGRVLWGSRSIGENT 291
            .....:||||:..||||....|..:..||::|::|||.:|::.|.:.||.:|..||||::|||.|
  Fly   245 VRGLSNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFLPIVSMTVTYSRVGIELWGSKTIGECT 309

  Fly   292 DRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQVASTKYVQHMYLGFYWLAMSNA 356
            .||:|:::|||:||:|.|.:|.||||||||:|.:||.......:....::|.:||..|||||||:
  Fly   310 PRQVENVRSKRRVVKMMIVVVLIFAICWLPFHSYFIITSCYPAITEAPFIQELYLAIYWLAMSNS 374

  Fly   357 MVNPLIYYWMNKRFRMYFQRIICCC---------------------CVGLTRH----RFDSPKSR 396
            |.||:||.|||.|||..|:.:...|                     |.|...|    |.|:.||.
  Fly   375 MYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTEPFSRRENLTSRYSCSGSPDHNRIKRNDTQKSI 439

  Fly   397 L-TNKNSSNRH------TRGGYTVAHSLP------------------------------------ 418
            | |..:|...|      |....|:.:|||
  Fly   440 LYTCPSSPKSHRISHSGTGRSATLRNSLPAESLSSGGSGGGGHRKRLSYQQEMQQRWSGPNSATA 504

  Fly   419 ----NSSPPTTQTLLAVLAQTLTQPKPQTQLLLSHHSPH 453
                :|:..|||.|. ..|..:..|:.|||::.|  ||:
  Fly   505 VTNSSSTANTTQLLSXQPAIQVVPPEMQTQIVCS--SPY 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	138/283 (49%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	126/262 (48%)
TkR99D	NP_001263092.1	7tm_4	113..396	CDD:304433	137/282 (49%)
TkR99D	NP_001263092.1	7tm_1	118..381	CDD:278431	126/262 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449187
Domainoid	1	1.000	255	1.000	Domainoid score	I2003
eggNOG	1	0.900	-	-		E1_KOG4219
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I2238
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314830at33208
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	1	1.000	-	-		mtm6420
orthoMCL	1	0.900	-	-		OOG6_105137
Panther	1	1.100	-	-	P	PTHR24238
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3520
SonicParanoid	1	1.000	-	-		X257
	12	11.830