DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and p2ry2

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_989039.1	Gene:	p2ry2 / 394636	XenbaseID:	XB-GENE-1005097	Length:	349	Species:	Xenopus tropicalis

Alignment Length:	368	Identity:	87/368 - (23%)
Similarity:	160/368 - (43%)	Gaps:	48/368 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 ECLFPSPTRPYELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADL 130
            :|.|....:...||        :.:|::..|.:..|.:.|:|..........:..::.||:|:|:
Frog    13 KCKFDEDFKYVLLP--------VSYGIVFCVGLILNILALYIFLFRIKPWNASTTYMFNLAISDM 69

  Fly   131 LMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRR--T 193
            :......:..:.:....:||||...|.|..|:....:..|:..|:.||..|::.|.:|:|..  .
Frog    70 MYVISLPLLVYYYSQGDNWPFGVALCKIVKFLFYTNMYCSISFLLCISIHRFLGICYPMKSLGWL 134

  Fly   194 SRRKVRIILVLIWALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMAD-----YA 253
            ..|..|||.|::|.:.....:|.|.:.:..:    ||.| |.|        :.||..|     ..
Frog   135 KVRNARIISVVVWVIVSACQSPILYFVTTSS----NGDS-TTC--------HDTSSVDLFDNFVV 186

  Fly   254 YNLIILVLTYGIPMIVMLICYSLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAIC 318
            |:.:.|.|.:.:|.|.::|||.||.|.|....:....|.      .||:|.::|.|.::::|.||
Frog   187 YSTVDLALLFCVPFITIIICYCLMARTLMKPSAATAQTS------ASKKKSIKMIIIVLAVFIIC 245

  Fly   319 WLPYHL-FFIYAYHNNQVASTKYVQHMYLGFYW---LAMSNAMVNPLIYYWMNKRFRMYFQRIIC 379
            :||:|: ..:|.|..........:..:.|.:..   ||.:|:.::|::|:...:..|    |.|
Frog   246 FLPFHINRTLYYYFRKMELDCDILNAINLAYKVTRPLASANSCLDPILYFLAGQTVR----RSI- 305

  Fly   380 CCCVGLTRHRFDSPKSRLTNKNSSNRHTRGGYTVAHSLPNSSP 422
                 :.|:.....|::.|:....|..:.....|::|....||
Frog   306 -----IPRNGLSKMKNKFTSYVLENNWSGSATGVSNSEARQSP 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	72/294 (24%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	69/273 (25%)
p2ry2	NP_989039.1	7tmA_P2Y2	23..305	CDD:320495	76/312 (24%)
		TM helix 1	23..50	CDD:320495	7/34 (21%)
		TM helix 2	57..82	CDD:320495	4/24 (17%)
		TM helix 3	95..125	CDD:320495	8/29 (28%)
		TM helix 4	137..159	CDD:320495	7/21 (33%)
		TM helix 5	184..213	CDD:320495	10/28 (36%)
		TM helix 6	226..256	CDD:320495	11/29 (38%)
		TM helix 7	273..298	CDD:320495	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910