Protein Alignment TkR86C and Hcrtr2

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_945200.1
• Gene: Hcrtr2 / 387285
• MGIID: 2680765
• Length: 460
• Species: Mus musculus
• Alignment Length: 434
• Identity: 117/434 - (26%)
• Similarity: 206/434 - (47%)
• Gaps: 65/434 - (14%)

  Fly    50 NRDNLESINEAKDFLTECLFPSPT------------RPYELPWEQKTIWAIIFG--LMMFVAIAG 100
            :|.|..|.:|..:  |:..|.:||            |.|..|.|.:  |.:|.|  ::..||:.|
Mouse    11 SRRNWSSASELNE--TQEPFLNPTDYDDEEFLRYLWREYLHPKEYE--WVLIAGYIIVFVVALIG 71

  Fly   101 NGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCV-FNFIFMLNSDWPFGSIYCTINNFVAN 164
            |.:|...|..:..||||||||::|||:||:|: ::.|: ...:..:...|.||...|.:..::..
Mouse    72 NVLVCVAVWKNHHMRTVTNYFIVNLSLADVLV-TITCLPATLVVDITETWFFGQSLCKVIPYLQT 135

  Fly   165 VTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVLIWALSCVLSAP--CLLYSSIMTKHY 227
            |:||.||.||..|:.||:.||.|||..:::.::.|..:|:||.:||::..|  .::..|.|....
Mouse   136 VSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMECSSMLPGL 200

  Fly   228 YNGKSR-TVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLMGRVLW-----GSRS 286
            .|..:. |||...|....||.     .|::...::||..|:.:|::.|..:.|.||     |:.|
Mouse   201 ANKTTLFTVCDEHWGGEVYPK-----MYHICFFLVTYMAPLCLMILAYLQIFRKLWCRQIPGTSS 260

  Fly   287 IGENTDRQ------------------------MESMKSKRKVVRMFIAIVSIFAICWLPYHLFFI 327
            :.:...:|                        ::.::::||..||.:.::.:||||:||..:..:
Mouse   261 VVQRKWKQQQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNV 325

  Fly   328 YAYHNNQVASTKYVQHMYLGF---YWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHR 389
            ..........|:..:.:|..|   :||..:|:..||:||.:::.:||..|:... .||:|:...:
Mouse   326 LKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAF-SCCLGVHHRQ 389

  Fly   390 FDSPKSRLTNKNSSNRHTRGGYTVAHSLPNSSPPTTQTLLAVLA 433
            .|    ||....:|....:...|...:..|.|..:...:|..::
Mouse   390 GD----RLARGRTSTESRKSLTTQISNFDNVSKLSEHVVLTSIS 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	93/327 (28%)
		TM helix 1	85..111	CDD:320512	9/27 (33%)
		TM helix 2	118..144	CDD:320512	11/26 (42%)
		TM helix 3	156..186	CDD:320512	12/29 (41%)
		TM helix 4	197..218	CDD:320512	7/22 (32%)
		TM helix 5	251..280	CDD:320512	6/28 (21%)
		TM helix 6	299..329	CDD:320512	10/29 (34%)
		TM helix 7	342..367	CDD:320512	9/27 (33%)
Hcrtr2	NP_945200.1	Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43614	33..49		2/15 (13%)
		7tmA_OXR	55..375	CDD:320336	93/325 (29%)
		TM helix 1	56..82	CDD:320336	8/25 (32%)
		TM helix 2	89..115	CDD:320336	11/26 (42%)
		TM helix 3	127..157	CDD:320336	12/29 (41%)
		TM helix 4	168..189	CDD:320336	7/20 (35%)
		TM helix 5	220..249	CDD:320336	7/33 (21%)
		TM helix 6	297..327	CDD:320336	10/29 (34%)
		TM helix 7	343..368	CDD:320336	9/24 (38%)
		Orexin_rec2	386..443	CDD:427531	8/48 (17%)