DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and Gpr35

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001032436.1	Gene:	Gpr35 / 367315	RGDID:	1309404	Length:	306	Species:	Rattus norvegicus

Alignment Length:	301	Identity:	71/301 - (23%)
Similarity:	134/301 - (44%)	Gaps:	34/301 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LPWEQKT--IWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADL-LMSSLNCVF 139
            |||....  |:.|...|::.:.:..||:.||:........|.|..::.||::||: |:.||..|.
  Rat     9 LPWPAAVNHIFTIYLVLLLVLGLLLNGLALWVFCYRMHQWTETRVYMTNLAVADVCLLCSLPFVL 73

  Fly   140 NFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSR--RKVRIIL 202
            ..:....||.|.    |.::..:..|....|:..:.||:.|||:|:.|||:.|..|  |:...:.
  Rat    74 YSLKYSTSDTPI----CQLSQGIYLVNRYMSISLVTAIAVDRYVAVRHPLRARELRSPRQAGAVC 134

  Fly   203 VLIWALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPM 267
            |.:|.         ::.:|::.:.....:....||.  ...||..|...::      :|.:.:|:
  Rat   135 VALWV---------IVVTSLVLRWRLGIQEGGFCFS--SQNRYNFSTTAFS------LLGFYLPL 182

  Fly   268 IVMLICYSLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFF-IYAYH 331
            .:::.|      .|....::.......:|.:::.:|..||..|.:::|.||:||.||.. :....
  Rat   183 AIVVFC------SLQVVTALARRPATDVEQVEATQKATRMVWANLAVFIICFLPLHLILTVQVSL 241

  Fly   332 NNQVASTKYVQHMYLGF-YWLAMSNAMVNPLIYYWMNKRFR 371
            |....:.:.:....|.. ..|:..|..::.:.||:|.|.|:
  Rat   242 NLHTCAARNIFSRALTITAKLSDINCCLDAICYYYMAKEFQ 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	66/285 (23%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	60/267 (22%)
Gpr35	NP_001032436.1	7tm_GPCRs	39..285	CDD:421689	62/271 (23%)
		TM helix 2	51..76	CDD:410628	9/24 (38%)
		TM helix 3	86..116	CDD:410628	9/29 (31%)
		TM helix 4	128..150	CDD:410628	4/30 (13%)
		TM helix 5	166..195	CDD:410628	6/40 (15%)
		TM helix 6	208..238	CDD:410628	11/29 (38%)
		TM helix 7	253..278	CDD:410628	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000