DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and CCHa2-R

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	356	Identity:	104/356 - (29%)
Similarity:	173/356 - (48%)	Gaps:	44/356 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 IWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCV-FNFIFMLNSD 148
            |..:::.|:..|.:.|||.::.|...|||||.:.|.::|:|::||||: .|.|| ...|......
  Fly    71 IVTVLYTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLALADLLV-ILVCVPVATIVYTQES 134

  Fly   149 WPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVLIWALSCVLS 213
            |||....|.|:.|..::::..|||||.|:|.:||.|||:||::..::.......|:||.|:.:|.
  Fly   135 WPFERNMCRISEFFKDISIGVSVFTLTALSGERYCAIVNPLRKLQTKPLTVFTAVMIWILAILLG 199

  Fly   214 APCLLYSSIMTKHYYNGKSR---TVCFMMWPDGRYPTSMADYAYNLII--LVLTYGIPMIVMLIC 273
            .|.:|:|.|.:...:.....   .||        .|....:||..::.  .::.|.:|:.::...
  Fly   200 MPSVLFSDIKSYPVFTATGNMTIEVC--------SPFRDPEYAKFMVAGKALVYYLLPLSIIGAL 256

  Fly   274 YSLMGRVLWGSRSIGENTDRQMESMKSKRK------VVRMFIAIVSIFAICWLPYHLFFIYAYHN 332
            |.:|.:.|..|   ..|...:.:||:|:.:      |.||.:|.|.:|.||:.|||:|.:: ||.
  Fly   257 YIMMAKRLHMS---ARNMPGEQQSMQSRTQARARLHVARMVVAFVVVFFICFFPYHVFELW-YHF 317

  Fly   333 NQVASTKYVQHMYLGFYW---------LAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCV----G 384
            ...|...:.:      :|         .:..|:.|||:..|.::..||.:|.|.:||.||    .
  Fly   318 YPTAEEDFDE------FWNVLRIVGFCTSFLNSCVNPVALYCVSGVFRQHFNRYLCCICVKRQPH 376

  Fly   385 LTRHRFDSPKSRLTNKNSSNRHTRGGYTVAH 415
            |.:|...:.....|:..|..|.|..|.|..:
  Fly   377 LRQHSTATGMMDNTSVMSMRRSTYVGGTAGN 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	90/304 (30%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	84/283 (30%)
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	90/309 (29%)
		TM helix 1	71..97	CDD:320593	7/25 (28%)
		TM helix 2	104..130	CDD:320593	11/26 (42%)
		TM helix 3	142..172	CDD:320593	13/29 (45%)
		TM helix 4	182..202	CDD:320593	5/19 (26%)
		TM helix 5	234..259	CDD:320593	4/24 (17%)
		TM helix 6	285..315	CDD:320593	12/30 (40%)
		TM helix 7	330..355	CDD:320593	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810