DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and Hcar2

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_852141.1	Gene:	Hcar2 / 353250	RGDID:	727952	Length:	360	Species:	Rattus norvegicus

Alignment Length:	361	Identity:	96/361 - (26%)
Similarity:	160/361 - (44%)	Gaps:	54/361 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 IFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFI---FMLNSDWP 150
            :.||.....:.|||:.|||...|......:..||.||::||.|:  :.|: .|:   ::.|.||.
  Rat    30 VLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLL--IICL-PFLTDNYVQNWDWR 91

  Fly   151 FGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHP--LKRRTSRRKVRIILVLIWALSCVLS 213
            ||||.|.:..|:..:....|:..|..::.|||..:|||  ...:.|.|...||...:|.::..|:
  Rat    92 FGSIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLT 156

  Fly   214 APCLLYSSIMTKHYYNG-----KSRTVCF-MMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLI 272
            .. |||:.:||:   ||     .|.::|: ..|.|..:              :|.:.:|:.::|.
  Rat   157 VH-LLYTDMMTR---NGDANLCSSFSICYTFRWHDAMF--------------LLEFFLPLGIILF 203

  Fly   273 CYSLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLP-----YHLFFIYAYHN 332
            |   .||::|..|      .|||:.....::.:...:.:..:|.||:||     ..:|::...||
  Rat   204 C---SGRIIWSLR------QRQMDRHVKIKRAINFIMVVAIVFVICFLPSVAVRIRIFWLLYKHN 259

  Fly   333 NQVASTKYVQHMYLGFYW---LAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPK 394
              |.:......:.|.|:.   ....|:|::|::||:.:..|..:|...|..|....|....|:.:
  Rat   260 --VRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRRKTLGEPDNNR 322

  Fly   395 S---RLTNKNSSNRHTRGGYTVAHSLPNSSPPTTQT 427
            |   .||...|:.|...|......|.|.|.|....|
  Rat   323 STSVELTGDPSTIRSIPGALMTDPSEPGSPPYLAST 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	80/302 (26%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	75/281 (27%)
Hcar2	NP_852141.1	7tmA_HCAR1-3	25..302	CDD:320329	80/303 (26%)
		TM helix 1	27..51	CDD:320329	8/20 (40%)
		TM helix 2	60..81	CDD:320329	9/23 (39%)
		TM helix 3	98..120	CDD:320329	3/21 (14%)
		TM helix 4	143..159	CDD:320329	4/16 (25%)
		TM helix 5	183..206	CDD:320329	6/39 (15%)
		TM helix 6	227..249	CDD:320329	5/21 (24%)
		TM helix 7	270..295	CDD:320329	7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..360		11/39 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000