Protein Alignment TkR86C and CCKLR-17D1

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Alignment Length: 517
• Identity: 105/517 - (20%)
• Similarity: 170/517 - (32%)
• Gaps: 209/517 - (40%)

  Fly    85 IWAI-IFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSD 148
            ||.: .:..::..|:.||.:|:..:..:|.|||:||.|||||:|:|:|:.........:..|...
  Fly   176 IWVVPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRH 240

  Fly   149 WPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRT--SRRKVRIILVLIWALSCV 211
            :.||.:.|.:..|....:|:.|.:||||||.:||.||.|||:.||  :......|:.:||..|.|
  Fly   241 FIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLV 305

  Fly   212 LSAPCLLYSSIMTKHYYNGKSR---TVCFMMWPDGRYPTSMADY--AYNLIILVLTYGIPMIVML 271
            ...|...:|.:|.      .||   ..|...|     |....:|  ||||.:.:....:|::.:.
  Fly   306 CMTPIAAFSQLMP------TSRPGLRKCREQW-----PADSLNYERAYNLFLDLALLVLPLLALS 359

  Fly   272 ICYSLMGRVLW------------------------------------------------------ 282
            ..|..:.|.|:
  Fly   360 FTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPH 424

  Fly   283 ----------------GSRS--------------------------------------------- 286
                            ||:.
  Fly   425 QQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGN 489

  Fly   287 ---------------------IGENTDR--------------------QMESMKSKRKVVRMFIA 310
                                 :.:|..|                    :.:|::||::||:|...
  Fly   490 GECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFV 554

  Fly   311 IVSIFAICWLPYHLFFIYAYHNNQVASTKYVQHMYLGF------YWLAMSNAMVNPLIYYWMNKR 369
            :|..|.|||.|.::.      |..........:.|:|:      ..||.|::..||:.|.:||..
  Fly   555 LVLEFFICWTPLYVI------NTMTMLLGPTVYEYVGYTSISFLQLLAYSSSCCNPITYCFMNAS 613

  Fly   370 FRMYF----------QRIICCCCVGLTRHRFDSPKSRLTNKNSSNRHTRG-GYTVAHSLPNS 420
            ||..|          :|:...||..           |..:||.:|....| ...:|:|:.:|
  Fly   614 FRRAFVDTFKGMRVCERLCAPCCFW-----------RRRSKNETNLSVAGNSIALANSVMSS 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	93/458 (20%)
		TM helix 1	85..111	CDD:320512	6/26 (23%)
		TM helix 2	118..144	CDD:320512	10/25 (40%)
		TM helix 3	156..186	CDD:320512	13/29 (45%)
		TM helix 4	197..218	CDD:320512	6/20 (30%)
		TM helix 5	251..280	CDD:320512	7/30 (23%)
		TM helix 6	299..329	CDD:320512	11/29 (38%)
		TM helix 7	342..367	CDD:320512	8/30 (27%)
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	92/457 (20%)
		TM helix 1	178..202	CDD:410628	4/23 (17%)
		TM helix 2	211..233	CDD:410628	9/21 (43%)
		TM helix 3	249..271	CDD:410628	8/21 (38%)
		TM helix 4	294..310	CDD:410628	5/15 (33%)
		TM helix 5	340..363	CDD:410628	5/22 (23%)
		TM helix 6	549..571	CDD:410628	8/27 (30%)
		TM helix 7	586..611	CDD:410628	6/24 (25%)