DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TkR86C and Gpr4

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001020851.1	Gene:	Gpr4 / 308408	RGDID:	1311604	Length:	365	Species:	Rattus norvegicus

Alignment Length:	400	Identity:	94/400 - (23%)
Similarity:	158/400 - (39%)	Gaps:	97/400 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 DFLTECLFPSPTRPYELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLS 126
            |...:.|||            .:::..:.|    |.:..|.:.||........|.....:|:|||
  Rat    14 DSRVDHLFP------------PSLYIFVIG----VGLPTNCLALWAAYRQVRQRNELGVYLMNLS 62

  Fly   127 IADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKR 191
            |||||......::...|:.:.:|..|...|.:..|:....:..|:..|..||.|||:|:.|||:.
  Rat    63 IADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYSNIYISIAFLCCISVDRYLAVAHPLRF 127

  Fly   192 RTSRRKVRIILV--LIWALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAY 254
            ...||....:.|  ::||.....::..|.:..:....|    :.|.||..:|..|:...|
  Rat   128 ARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRY----NHTFCFEKFPMERWVAWM----- 183

  Fly   255 NLIILVLTYGIPMIVMLICYSLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICW 319
            ||..:.:.:..|..:||:||..:.|.:..|.|    |:||     .|.|:.|:.:::::|..:|:
  Rat   184 NLYRVFVGFLFPWALMLLCYRGILRAVQSSVS----TERQ-----EKVKIKRLALSLIAIVLVCF 239

  Fly   320 LPYHLFFIYAYHNNQVASTKYVQHMYLGFYW---------------LAMS--NAMVNPLIYYWMN 367
            .|||...:..            ..:|||..|               ||.:  |.:.:|::|..:|
  Rat   240 APYHALLLSR------------SAVYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVN 292

  Fly   368 KRFRMYFQRIICCCCVGLTRH---RF---DSP----------KSRLTNKNSSNRHTRGGYTVAHS 416
            :..|....:.:         |   ||   :.|          ::.||:|.|:...|.|.....
  Rat   293 EGARSDVAKAL---------HNLLRFLASNKPQEMANASLTLETPLTSKRSTTGKTSGAVWAV-- 346

  Fly   417 LPNSSPPTTQ 426
                 |||.|
  Rat   347 -----PPTAQ 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	75/302 (25%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	71/281 (25%)
Gpr4	NP_001020851.1	7tmA_GPR4	20..299	CDD:320488	79/324 (24%)
		TM helix 1	22..46	CDD:320488	6/39 (15%)
		TM helix 2	55..76	CDD:320488	9/20 (45%)
		TM helix 3	93..115	CDD:320488	4/21 (19%)
		TM helix 4	138..154	CDD:320488	3/15 (20%)
		TM helix 5	181..204	CDD:320488	7/27 (26%)
		TM helix 6	225..247	CDD:320488	6/21 (29%)
		TM helix 7	267..292	CDD:320488	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000