Protein Alignment TkR86C and HCRTR2

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: XP_016866287.1
• Gene: HCRTR2 / 3062
• HGNCID: 4849
• Length: 461
• Species: Homo sapiens
• Alignment Length: 487
• Identity: 131/487 - (26%)
• Similarity: 221/487 - (45%)
• Gaps: 101/487 - (20%)

  Fly    50 NRDNLESINEAKDFLTECLFPSPT------------RPYELPWEQKTIWAIIFG--LMMFVAIAG 100
            |..:...:||     |:..|.:||            |.|..|.|.:  |.:|.|  ::..||:.|
Human    14 NWSSASELNE-----TQEPFLNPTDYDDEEFLRYLWREYLHPKEYE--WVLIAGYIIVFVVALIG 71

  Fly   101 NGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCV-FNFIFMLNSDWPFGSIYCTINNFVAN 164
            |.:|...|..:..||||||||::|||:||:|: ::.|: ...:..:...|.||...|.:..::..
Human    72 NVLVCVAVWKNHHMRTVTNYFIVNLSLADVLV-TITCLPATLVVDITETWFFGQSLCKVIPYLQT 135

  Fly   165 VTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVLIWALSCVLSAPCLLYSSIMTKHYYN 229
            |:||.||.||..|:.||:.||.|||..:::.::.|..:|:||.:||::..|..:.....|  .:.
Human   136 VSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECST--VFP 198

  Fly   230 GKSR-----TVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLMGRVLW-----GS 284
            |.:.     |||...|....||.     .|::...::||..|:.:|::.|..:.|.||     |:
Human   199 GLANKTTLFTVCDERWGGEIYPK-----MYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGT 258

  Fly   285 RSI-----------------GENTDRQM-------ESMKSKRKVVRMFIAIVSIFAICWLPYHLF 325
            .|:                 |:.|..:|       :.::::||..||.:.::.:||||:||..:.
Human   259 SSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISIL 323

  Fly   326 FIYAYHNNQVASTKYVQHMYLGF---YWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTR 387
            .:........|.|:..:.:|..|   :||..:|:..||:||.:::.:||..|:....|||:|: .
Human   324 NVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGV-H 387

  Fly   388 HRFDSPKSRLTNKNSSNRHTRGGYTVAHSLPNSSPPTTQTLLAVLAQTLTQPKPQTQLLLSHHSP 452
            ||   .:.|||...:|....:...|...:..|.|..:.|.:|..::
Human   388 HR---QEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSIS------------------- 430

  Fly   453 HPTQPSA--AETKSQWKRSTMETQIQQAPVTS 482
              |.|:|  |.....|       .:||.|.:|
Human   431 --TLPAANGAGPLQNW-------CLQQGPPSS 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	95/329 (29%)
		TM helix 1	85..111	CDD:320512	9/27 (33%)
		TM helix 2	118..144	CDD:320512	11/26 (42%)
		TM helix 3	156..186	CDD:320512	12/29 (41%)
		TM helix 4	197..218	CDD:320512	7/20 (35%)
		TM helix 5	251..280	CDD:320512	6/28 (21%)
		TM helix 6	299..329	CDD:320512	10/29 (34%)
		TM helix 7	342..367	CDD:320512	9/27 (33%)
HCRTR2	XP_016866287.1	7tmA_OXR	55..375	CDD:320336	95/327 (29%)
		TM helix 1	56..82	CDD:320336	8/25 (32%)
		TM helix 2	89..115	CDD:320336	11/26 (42%)
		TM helix 3	127..157	CDD:320336	12/29 (41%)
		TM helix 4	168..189	CDD:320336	7/20 (35%)
		TM helix 5	220..249	CDD:320336	7/33 (21%)
		TM helix 6	297..327	CDD:320336	10/29 (34%)
		TM helix 7	343..368	CDD:320336	9/24 (38%)
		Orexin_rec2	387..444	CDD:427531	15/80 (19%)