DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and P2ry2

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_058951.2	Gene:	P2ry2 / 29597	RGDID:	62088	Length:	374	Species:	Rattus norvegicus

Alignment Length:	432	Identity:	82/432 - (18%)
Similarity:	164/432 - (37%)	Gaps:	119/432 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 ECLFPSPTRPYELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADL 130
            :|.|....:...||        :.:|::..:.:..|.:.|:|..........:..::.:|:::|.
  Rat    24 KCRFNEDFKYVLLP--------VSYGVVCVLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDS 80

  Fly   131 LMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRT-- 193
            |.::...:..:.:.....|||.::.|.:..|:....:..|:..|..||..|.:.::.||...:
  Rat    81 LYAASLPLLVYYYAQGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLHSLSWG 145

  Fly   194 SRRKVRIILVLIWALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMAD-----YA 253
            ..|..|.:..::|.|.....||.|.:.:...:     .:|..|        :.||..:     .|
  Rat   146 HARYARRVAAVVWVLVLACQAPVLYFVTTSVR-----GTRITC--------HDTSARELFSHFVA 197

  Fly   254 YNLIILVLTYGIPMIVMLICYSLMGRVL----WGSRSIGENTDRQMESMKSKRKVVRMFIAIVSI 314
            |:.::|.|.:.:|..::|:||.||.|.|    :|:..:          .::|||.||....::::
  Rat   198 YSSVMLGLLFAVPFSIILVCYVLMARRLLKPAYGTTGL----------PRAKRKSVRTIALVLAV 252

  Fly   315 FAICWLPYH----LFFIYAYHNNQVASTKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQ 375
            ||:|:||:|    |::.:...:....:...:...|.....||.:|:.::|::|:...:|. :.|.
  Rat   253 FALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKITRPLASANSCLDPVLYFLAGQRL-VRFA 316

  Fly   376 RIICCCCVGLTRHRFDSPKSRLTNKNSSNRHTRGGYTVAHSLPNSSPPTTQTLLAVLAQTLTQPK 440
            |                                          ::.|.|..|           |.
  Rat   317 R------------------------------------------DAKPATEPT-----------PS 328

  Fly   441 PQTQLLLSHHSPHPTQ-------------------PSAAETK 463
            ||.:..|..|.|:.|.                   |:.:|||
  Rat   329 PQARRKLGLHRPNRTDTVRKDLSISSDDSRRTESTPAGSETK 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	62/298 (21%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	59/277 (21%)
P2ry2	NP_058951.2	7tmA_P2Y2	34..316	CDD:320495	64/313 (20%)
		TM helix 1	36..60	CDD:320495	6/31 (19%)
		TM helix 2	69..90	CDD:320495	3/20 (15%)
		TM helix 3	107..129	CDD:320495	4/21 (19%)
		TM helix 4	152..168	CDD:320495	3/15 (20%)
		TM helix 5	196..219	CDD:320495	7/22 (32%)
		TM helix 6	243..265	CDD:320495	8/21 (38%)
		TM helix 7	284..309	CDD:320495	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000