Protein Alignment TkR86C and Oprl1

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_001305876.1
• Gene: Oprl1 / 29256
• RGDID: 68438
• Length: 396
• Species: Rattus norvegicus
• Alignment Length: 378
• Identity: 104/378 - (27%)
• Similarity: 174/378 - (46%)
• Gaps: 69/378 - (18%)

  Fly    66 ECLFPSP-------------------TRPYE----------LPWEQKTIWAIIFGLMMFVAIA-- 99
            |.|||:|                   |.|:.          ||...|   ..|.||.:.|.|.
  Rat     2 ESLFPAPYWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLK---VTIVGLYLAVCIGGL 63

  Fly   100 -GNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVA 163
             ||.:|::::..|..|:|.||.::.||::||.|: .|...|....:|...||||:..|.....:.
  Rat    64 LGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAID 127

  Fly   164 NVTVSTSVFTLVAISFDRYIAIVHPLKR---RTSRRKVRIILVLIWALSCVLSAPCLLYSSIMTK 225
            ...:.||.|||.|:|.|||:||.||::.   ||| .|.:.:.|.||||:.|:..|..:..|...:
  Rat   128 YYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTS-SKAQAVNVAIWALASVVGVPVAIMGSAQVE 191

  Fly   226 HYYNGKSRTVCFMMWPDGRYPTSMADY---AYNLIILVLTYGIPMIVMLICYSLMGRVLWGSRSI 287
                 .....|.:..|      :..||   .:.:.|.:.::.||::::.:|||||.|.|.|.|.:
  Rat   192 -----DEEIECLVEIP------APQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLL 245

  Fly   288 GENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQVASTKYVQHM----YLGF 348
            ..:.::.    ::.|::.|:.:.:|::|..||.|..:|.:......|..|...|..:    .||:
  Rat   246 SGSREKD----RNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGY 306

  Fly   349 YWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPKSRLTNKN 401
            .     |:.:||::|.::::.|:..|::.  ||...|.|....|.:.|...|:
  Rat   307 V-----NSCLNPILYAFLDENFKACFRKF--CCASSLHREMQVSDRVRSIAKD 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	86/302 (28%)
		TM helix 1	85..111	CDD:320512	8/28 (29%)
		TM helix 2	118..144	CDD:320512	9/25 (36%)
		TM helix 3	156..186	CDD:320512	12/29 (41%)
		TM helix 4	197..218	CDD:320512	8/20 (40%)
		TM helix 5	251..280	CDD:320512	10/31 (32%)
		TM helix 6	299..329	CDD:320512	8/29 (28%)
		TM helix 7	342..367	CDD:320512	6/28 (21%)
Oprl1	NP_001305876.1	7tmA_NOFQ_opioid_R	49..327	CDD:320220	86/299 (29%)
		TM helix 1	50..76	CDD:320220	8/25 (32%)
		TM helix 2	83..109	CDD:320220	9/26 (35%)
		TM helix 3	120..150	CDD:320220	12/29 (41%)
		TM helix 4	162..184	CDD:320220	8/21 (38%)
		TM helix 5	209..238	CDD:320220	8/28 (29%)
		TM helix 6	253..283	CDD:320220	8/29 (28%)
		TM helix 7	295..320	CDD:320220	7/29 (24%)