Protein Alignment TkR86C and Hcrtr2

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_037206.1
• Gene: Hcrtr2 / 25605
• RGDID: 2788
• Length: 460
• Species: Rattus norvegicus
• Alignment Length: 421
• Identity: 117/421 - (27%)
• Similarity: 201/421 - (47%)
• Gaps: 65/421 - (15%)

  Fly    51 RDNLESINEAKDFLTECLFPSPT------------RPYELPWEQKTIWAIIFG--LMMFVAIAGN 101
            |.|..|.:|..:  |:..|.:||            |.|..|.|.:  |.:|.|  ::..||:.||
  Rat    12 RRNWSSASELNE--TQEPFLNPTDYDDEEFLRYLWREYLHPKEYE--WVLIAGYIIVFVVALIGN 72

  Fly   102 GIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCV-FNFIFMLNSDWPFGSIYCTINNFVANV 165
            .:|...|..:..||||||||::|||:||:|: ::.|: ...:..:...|.||...|.:..::..|
  Rat    73 VLVCVAVWKNHHMRTVTNYFIVNLSLADVLV-TITCLPATLVVDITETWFFGQSLCKVIPYLQTV 136

  Fly   166 TVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVLIWALSCVLSAP--CLLYSSIMTKHYY 228
            :||.||.||..|:.||:.||.|||..:::.::.|..:|:||.:||::..|  .::..|.|.....
  Rat   137 SVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLA 201

  Fly   229 NGKSR-TVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLMGRVLW-----GSRSI 287
            |..:. |||...|....||.     .|::...::||..|:.:|::.|..:.|.||     |:.|:
  Rat   202 NKTTLFTVCDERWGGEVYPK-----MYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSV 261

  Fly   288 GENTDRQ------------------------MESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIY 328
            .:...:|                        ::.::::||..||.:.::.:||||:||..:..:.
  Rat   262 VQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVL 326

  Fly   329 AYHNNQVASTKYVQHMYLGF---YWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHRF 390
            .........|:..:.:|..|   :||..:|:..||:||.:::.:||..|:... .||:|:.|.:.
  Rat   327 KRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAF-SCCLGVHRRQG 390

  Fly   391 DSPKSRLTNKNSSNRHTRGGYTVAHSLPNSS 421
            |    ||....:|....:...|...:..|.|
  Rat   391 D----RLARGRTSTESRKSLTTQISNFDNVS 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	93/327 (28%)
		TM helix 1	85..111	CDD:320512	9/27 (33%)
		TM helix 2	118..144	CDD:320512	11/26 (42%)
		TM helix 3	156..186	CDD:320512	12/29 (41%)
		TM helix 4	197..218	CDD:320512	7/22 (32%)
		TM helix 5	251..280	CDD:320512	6/28 (21%)
		TM helix 6	299..329	CDD:320512	10/29 (34%)
		TM helix 7	342..367	CDD:320512	9/27 (33%)
Hcrtr2	NP_037206.1	Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43614	33..49		2/15 (13%)
		7tmA_OXR	55..375	CDD:320336	93/325 (29%)
		TM helix 1	56..82	CDD:320336	8/25 (32%)
		TM helix 2	89..115	CDD:320336	11/26 (42%)
		TM helix 3	127..157	CDD:320336	12/29 (41%)
		TM helix 4	168..189	CDD:320336	7/20 (35%)
		TM helix 5	220..249	CDD:320336	7/33 (21%)
		TM helix 6	297..327	CDD:320336	10/29 (34%)
		TM helix 7	343..368	CDD:320336	9/24 (38%)
		Orexin_rec2	386..443	CDD:427531	8/36 (22%)