Protein Alignment TkR86C and Nmbr

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_036931.1
• Gene: Nmbr / 25264
• RGDID: 3181
• Length: 390
• Species: Rattus norvegicus
• Alignment Length: 420
• Identity: 110/420 - (26%)
• Similarity: 191/420 - (45%)
• Gaps: 69/420 - (16%)

  Fly    25 SIVNTTLLGSLNRTEVVSLLSSIIDNRDNLESINEAKDFLTECLFPSPTRPYELPWEQKTIWAII 89
            |:.|.:|....:.:|   |...:.:|....:|.....:.:..|:.||                 :
  Rat     5 SLPNLSLPTEASESE---LEPEVWENDFLPDSDGTTAELVIRCVIPS-----------------L 49

  Fly    90 FGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCV----FNFIFMLNSDWP 150
            :.:::.|.:.||.:::.|...:.:||:|.|.|:.||:..|||: .|.||    ..:.|   .:|.
  Rat    50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLL-LLTCVPVDASRYFF---DEWV 110

  Fly   151 FGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIIL------VLIWALS 209
            ||.:.|.:...:...:|..|||||.|:|.|||.|||:|:..:||    .::|      |.||.:|
  Rat   111 FGKLGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTS----GVVLWTSLKAVGIWVVS 171

  Fly   210 CVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTS--MADYAYNLIILVLTYGIPMIVMLI 272
            .:|:.|..::|.:......:..|.|.|.      .||.:  :....::::|.::.:.||::::.|
  Rat   172 VLLAVPEAVFSEVARIGSSDNSSFTACI------PYPQTDELHPKIHSVLIFLVYFLIPLVIISI 230

  Fly   273 CYSLMGRVLWGSR-----SIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHN 332
            .|..:.:.|..|.     ...|:|.:|||:.|...|:|.:|   |..|..||.|.|:.::|...|
  Rat   231 YYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVF---VGCFVFCWFPNHILYLYRSFN 292

  Fly   333 NQVASTKYVQHMYLGFY--WLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVG-------LTRH 388
            .:..... :.||.:...  .|:.||:.|||...|.:::.||.:|...:||   |       .|.:
  Rat   293 YKEIDPS-LGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHFNSQLCC---GQKSYPERSTSY 353

  Fly   389 RFDSPKSRLTN--KNSSNRHTRGGYTVAHS 416
            ...|...|:|:  .|:.|..|.......||
  Rat   354 LLSSSAVRMTSLKSNAKNVVTNSVLLNGHS 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	87/308 (28%)
		TM helix 1	85..111	CDD:320512	4/25 (16%)
		TM helix 2	118..144	CDD:320512	10/29 (34%)
		TM helix 3	156..186	CDD:320512	13/29 (45%)
		TM helix 4	197..218	CDD:320512	7/26 (27%)
		TM helix 5	251..280	CDD:320512	5/28 (18%)
		TM helix 6	299..329	CDD:320512	10/29 (34%)
		TM helix 7	342..367	CDD:320512	9/26 (35%)
Nmbr	NP_036931.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		4/17 (24%)
		7tm_GPCRs	44..335	CDD:475119	90/325 (28%)
		TM helix 1	46..70	CDD:410628	6/40 (15%)
		TM helix 2	79..101	CDD:410628	10/22 (45%)
		TM helix 3	117..139	CDD:410628	7/21 (33%)
		TM helix 4	162..178	CDD:410628	5/15 (33%)
		TM helix 5	210..233	CDD:410628	4/22 (18%)
		TM helix 6	265..287	CDD:410628	9/24 (38%)
		TM helix 7	303..328	CDD:410628	8/24 (33%)