Protein Alignment TkR86C and Prlhr

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_631932.4
• Gene: Prlhr / 246075
• RGDID: 71037
• Length: 370
• Species: Rattus norvegicus
• Alignment Length: 330
• Identity: 94/330 - (28%)
• Similarity: 165/330 - (50%)
• Gaps: 49/330 - (14%)

  Fly    71 SPTRPYELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSL 135
            :|.:..:|..:.|.:..:::.:::.|.:.||.:::.::...|.:..|||:.:.||:::|:||.:.
  Rat    48 TPFQSLQLVHQLKGLIVMLYSIVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCAA 112

  Fly   136 NCVFNFIFMLN-SDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVR 199
            .......:... ..|.||...|.:..|:..|||..|||||..|:.|||:.:||||:||.|.:...
  Rat   113 CVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLKLSA 177

  Fly   200 IILVLIWALSCVLSAPCLLYSSIMTKHYYNGKSR----TVCFMMWPDGRYPTSMADYAYNLIILV 260
            ..::.|||||.||:.|..:       |.|:.:.:    .:|...|  |........||:.|  |:
  Rat   178 YAVLGIWALSAVLALPAAV-------HTYHVELKPHDVRLCEEFW--GSQERQRQIYAWGL--LL 231

  Fly   261 LTYGIPMIVMLICY-----SLMGRVLWGSRSIGE-NTDRQMESMKSKRKVVRMFIAIVSIFAICW 319
            .||.:|::.:|:.|     .|..||:.||.:..: :.||     ..:|:...:.:.:|.:||:||
  Rat   232 GTYLLPLLAILLSYVRVSVKLRNRVVPGSVTQSQADWDR-----ARRRRTFCLLVVVVVVFAVCW 291

  Fly   320 LPYHLFFI-----------YAYHNNQVASTKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMY 373
            ||.|:|.:           ||:...|:..           :|||||:|..||.||.|::..||..
  Rat   292 LPLHIFNLLRDLDPRAIDPYAFGLVQLLC-----------HWLAMSSACYNPFIYAWLHDSFREE 345

  Fly   374 FQRII 378
            .::::
  Rat   346 LRKML 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	91/311 (29%)
		TM helix 1	85..111	CDD:320512	3/25 (12%)
		TM helix 2	118..144	CDD:320512	7/25 (28%)
		TM helix 3	156..186	CDD:320512	14/29 (48%)
		TM helix 4	197..218	CDD:320512	8/20 (40%)
		TM helix 5	251..280	CDD:320512	10/33 (30%)
		TM helix 6	299..329	CDD:320512	10/40 (25%)
		TM helix 7	342..367	CDD:320512	11/24 (46%)
Prlhr	NP_631932.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34
		7tmA_PrRP_R	61..346	CDD:320516	91/311 (29%)
		TM helix 1	62..88	CDD:320516	3/25 (12%)
		TM helix 2	95..120	CDD:320516	7/24 (29%)
		TM helix 3	134..164	CDD:320516	14/29 (48%)
		TM helix 4	175..196	CDD:320516	8/20 (40%)
		TM helix 5	222..251	CDD:320516	9/30 (30%)
		TM helix 6	271..301	CDD:320516	10/29 (34%)
		TM helix 7	314..339	CDD:320516	12/35 (34%)
		Required for interaction with GRIP1, GRIP2 and PICK1. /evidence=ECO:0000250	365..370