DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and Hcar1

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_780729.3	Gene:	Hcar1 / 243270	MGIID:	2441671	Length:	343	Species:	Mus musculus

Alignment Length:	340	Identity:	82/340 - (24%)
Similarity:	142/340 - (41%)	Gaps:	53/340 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 LMMFVAIA-GNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIY 155
            :::||..| ||||.|.....|......:..:|.||::||.|:.....:....::....|.||.|.
Mouse    23 ILVFVLGALGNGIALCGFCFHMKTWKSSTIYLFNLAVADFLLMICLPLRTDYYLRRRHWIFGDIA 87

  Fly   156 CTINNFVANVTVSTSVFTLVAISFDRYIAIVHP--LKRRTSRRKVRIILVLIWALSCVLSAPCLL 218
            |.:..|...:..:.|:..|..::.|||..:|||  :....|.|.......::|.| .:|....||
Mouse    88 CRLVLFKLAMNRAGSIVFLTVVAVDRYFKVVHPHHMVNAISNRTAAATACVLWTL-VILGTVYLL 151

  Fly   219 YSSIMTKHYYNGKSRTVC--FMM-----WPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSL 276
                |..|.....:.:.|  |:|     |.|              ::..|.:.:|:.::|.|
Mouse   152 ----MESHLCVQGTLSSCESFIMESANGWHD--------------VMFQLEFFLPLTIILFC--- 195

  Fly   277 MGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLP---YHLFFIYAYHNNQV-AS 337
            ...|:|..|     ..:|:......|:..|..:.:.|:|..|:||   ..|:|::....:.. .|
Mouse   196 SVNVVWSLR-----RRQQLTRQARMRRATRFIMVVASVFITCYLPSVLARLYFLWTVPTSACDPS 255

  Fly   338 TKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCV------GLTRHRFDSPKSR 396
            .....|:.|.|.:|   |:|::||:||:.:.....::.::..|...      ..||...:.|.|.
Mouse   256 VHTALHVTLSFTYL---NSMLDPLVYYFSSPSLPKFYTKLTICSLKPKRPGRTKTRRSEEMPISN 317

  Fly   397 LTNKNS---SNRHTR 408
            |.:|:|   :||..|
Mouse   318 LCSKSSIDGANRSQR 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	71/297 (24%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	66/275 (24%)
Hcar1	NP_780729.3	7tmA_HCAR1-3	16..289	CDD:320329	71/295 (24%)
		TM helix 1	17..43	CDD:320329	8/19 (42%)
		TM helix 2	50..75	CDD:320329	6/24 (25%)
		TM helix 3	88..118	CDD:320329	7/29 (24%)
		TM helix 4	130..152	CDD:320329	6/26 (23%)
		TM helix 5	173..202	CDD:320329	7/45 (16%)
		TM helix 6	213..243	CDD:320329	8/29 (28%)
		TM helix 7	257..282	CDD:320329	10/27 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..343		5/14 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000