DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and P2ry6

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_898991.1	Gene:	P2ry6 / 233571	MGIID:	2673874	Length:	328	Species:	Mus musculus

Alignment Length:	303	Identity:	69/303 - (22%)
Similarity:	134/303 - (44%)	Gaps:	45/303 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 IFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGS 153
            ::.:::.|.:..|..|:..:...|...|.:..:.|||::|||:.:....:..:.:.....||||.
Mouse    32 VYSVVLVVGLPLNICVIAQICASRRTLTRSAVYTLNLALADLMYACSLPLLIYNYARGDHWPFGD 96

  Fly   154 IYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPL---KRRTSRRKVRIILVLIWALSCVLSAP 215
            :.|....|:....:..|:..|..|||.||:.|.|||   .:|..||...::..::|........|
Mouse    97 LACRFVRFLFYANLHGSILFLTCISFQRYLGICHPLASWHKRGGRRAAWVVCGVVWLAVTAQCLP 161

  Fly   216 CLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADY-AYNLIILVLTYGIPMIVMLICYSLMGR 279
            ..::::...:     ::||||:.:.|    |.....| .|.:.:.|:.:.:|.|.:|.||..|.|
Mouse   162 TAVFAATGIQ-----RNRTVCYDLSP----PILSTRYLPYGMALTVIGFLLPFIALLACYCRMAR 217

  Fly   280 VLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQVASTKYV--- 341
                 |...::......:.:.:.|..||.:.:.::|||.:||:|           :..|.|:
Mouse   218 -----RLCRQDGPAGPVAQERRSKAARMAVVVAAVFAISFLPFH-----------ITKTAYLAVR 266

  Fly   342 -------------QHMYLGFYWLAMSNAMVNPLIYYWMNKRFR 371
                         ...|.|....|..|::::|:::|:..::||
Mouse   267 STPGVSCPVLETFAAAYKGTRPFASVNSVLDPILFYFTQQKFR 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	69/300 (23%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	65/282 (23%)
P2ry6	NP_898991.1	7tm_GPCRs	27..312	CDD:421689	69/303 (23%)
		TM helix 1	27..54	CDD:410628	3/21 (14%)
		TM helix 2	61..86	CDD:410628	6/24 (25%)
		TM helix 3	99..129	CDD:410628	9/29 (31%)
		TM helix 4	142..164	CDD:410628	3/21 (14%)
		TM helix 5	189..218	CDD:410628	10/33 (30%)
		TM helix 6	232..262	CDD:410628	10/40 (25%)
		TM helix 7	280..305	CDD:410628	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000