DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and Tacr3

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_067357.1	Gene:	Tacr3 / 21338	MGIID:	892968	Length:	452	Species:	Mus musculus

Alignment Length:	462	Identity:	156/462 - (33%)
Similarity:	252/462 - (54%)	Gaps:	53/462 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LLGSLNRTEVVSLLSSIIDNRDNLESINEAKDFLTECLFPSPTRPYELPWEQKTIWAIIFGLMMF 95
            |..:|..||.::|.:....:...|...::|...:...|    |..:..|..:..:|::.:||::.
Mouse    24 LSAALGITEWLALQAGNFSSALGLPVTSQAPSQVRANL----TNQFVQPSWRIALWSLAYGLVVA 84

  Fly    96 VAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINN 160
            ||:.||.||:||:..|:.|||||||||:||:.:|..:::.|.:.|||:.::|:|.||:.||...|
Mouse    85 VAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLVNFIYGVHSEWYFGANYCRFQN 149

  Fly   161 FVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVLIWALSCVLSAPCLLYSSIMTK 225
            |.....|..|::::.||:.|||:||:.|||.|.|....:|::..||.|:.:|:.|..|||.|...
Mouse   150 FFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVM 214

  Fly   226 HYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLMGRVLWGSRSIGEN 290
                 ..||:|::.||:|    ....:.|::|:::|.|..|:::|.:.|:::|..|||....|:.
Mouse   215 -----PGRTLCYVQWPEG----PKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDT 270

  Fly   291 TDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQVASTKYVQHMYLGFYWLAMSN 355
            .|:..|.:|:|||||:|.|.:|..|||||||||::||......|:...||:|.:||..:|||||:
Mouse   271 CDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSS 335

  Fly   356 AMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPKSRLTNKNSSNRHTRGGYTVAHSLPNS 420
            .|.||:||..:|||||..|:|....|           |..::::.:.....|    |..|
Mouse   336 TMYNPIIYCCLNKRFRAGFKRAFRWC-----------PFIQVSSYDELELKT----TRFH----- 380

  Fly   421 SPPTTQTLLAVLAQTLTQPKPQTQLLLSHHSPHPTQPSAAETKSQWKRSTMETQIQQAPVTSSC- 484
              ||.|:.|    .|:::.:..|.|    :.|....|:.:..|   ||:     :.:.|..:.|
Mouse   381 --PTRQSSL----YTVSRMESVTVL----YDPSEGDPAKSSRK---KRA-----VPRDPSANGCS 427

  Fly   485 -REQRSA 490
             ||.:||
Mouse   428 HREFKSA 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	120/283 (42%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	109/262 (42%)
Tacr3	NP_067357.1	7tm_4	81..>204	CDD:304433	53/122 (43%)
		7tm_1	89..343	CDD:278431	109/262 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..452		11/42 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	1	1.000	-	-		mtm8831
orthoMCL	1	0.900	-	-		OOG6_105137
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3520
SonicParanoid	1	1.000	-	-		X257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.700