DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and npr-22

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001023541.1	Gene:	npr-22 / 190424	WormBaseID:	WBGene00022004	Length:	434	Species:	Caenorhabditis elegans

Alignment Length:	437	Identity:	118/437 - (27%)
Similarity:	198/437 - (45%)	Gaps:	82/437 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SLLSSIIDNRDNLESINEAKDFLTECLFPSPTRP---------YELPWEQKTIWAIIFGLMMFVA 97
            ||||.|......:...||          |:.|..         |.|....|.:..:.:.::....
Worm    10 SLLSRITTTASEIMMRNE----------PTTTENPAVQEMNHIYHLTPSMKMLCILFYSILCVCC 64

  Fly    98 IAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSD---WPFGSIYCTIN 159
            :.||.:|:.::...:.:||.||..:|||::||||:|.....|::..:|..|   |.|||:.|::.
Worm    65 VYGNVLVILVIVYFKRLRTATNILILNLAVADLLISVFCIPFSYWQVLIYDDQRWLFGSMMCSLL 129

  Fly   160 NFVANVTVSTSVFTLVAISFDRYIAIVHPL--KRRTSRRKVRIILVLIWALSCVLSAPCLLYSSI 222
            .|:..:.|..|.:|||.|||||::||:..|  ..|.:||:...::...|..|.:::.| ||::
Worm   130 AFLQAMAVFLSAWTLVVISFDRWMAIMFLLTPNIRITRRRALYLVAATWIFSILMALP-LLFT-- 191

  Fly   223 MTKHYYNGKSRTVCFMMWPDGRYPTSMAD------YAYNLIILVLTYGIPMIVMLICYSLMGRVL 281
             |:.:.:......|...|      |...|      ..|:.::|:|.|.:|..|::|.|:.:|..:
Worm   192 -TRFFEDQDGLPNCGENW------TYFGDSGEQVRKVYSSMVLILQYVVPQAVLIITYTHIGIKM 249

  Fly   282 WGSRSIG--ENTDRQM--ESMKSKRKVVRMFIAIVSIFAICWLPYHLFF-IYAYHNNQVASTKYV 341
            |.||..|  ....::|  :..:|.:|:|.|.|.|.::||:||||..:.. :.......:.|..|:
Worm   250 WNSRVPGMQNGATKKMIVDRHESVKKLVPMVILISALFALCWLPLLILINVIPEFYPDINSWGYI 314

  Fly   342 QHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCC--------CVGLTRHRFDSPKSRLT 398
            .:::...:.||||::||||:||:..|.|||..|      |        |:.....|.      ||
Worm   315 LYLWWFAHGLAMSHSMVNPIIYFIRNARFREGF------CFFSSKLLPCISFKELRL------LT 367

  Fly   399 NKNSSNRHTRGGYTVAHSLPNSSPPTTQTLLAVLAQTLTQPKPQTQL 445
            :..|.:...|..::                 .|:..|.:..||.|.|
Worm   368 DNTSRSFRNRSRFS-----------------GVINPTSSDEKPATSL 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	93/299 (31%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	86/278 (31%)
npr-22	NP_001023541.1	7tmA_PR4-like	51..347	CDD:320514	92/305 (30%)
		TM helix 1	52..78	CDD:320514	3/25 (12%)
		TM helix 2	85..110	CDD:320514	11/24 (46%)
		TM helix 3	126..156	CDD:320514	13/29 (45%)
		TM helix 4	169..190	CDD:320514	4/21 (19%)
		TM helix 5	219..248	CDD:320514	9/28 (32%)
		TM helix 6	271..301	CDD:320514	12/29 (41%)
		TM helix 7	315..340	CDD:320514	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314830at33208
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920