Protein Alignment TkR86C and npr-4

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_001300304.1
• Gene: npr-4 / 182684
• WormBaseID: WBGene00007635
• Length: 490
• Species: Caenorhabditis elegans
• Alignment Length: 513
• Identity: 112/513 - (21%)
• Similarity: 214/513 - (41%)
• Gaps: 104/513 - (20%)

  Fly    15 ILAVRRFELNSIVNTTLLGS-LNRTEVVSLLSSIIDNRDNLESINEAKDFLTECLFPSPTRPYEL 78
            :|.:....:.:|......|. :|.::.::|.|.:...|::|.|
 Worm     2 LLEIGTITIGNITRARKFGERMNGSDCLNLNSELWLYREDLSS---------------------- 44

  Fly    79 PWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIF 143
            .|....::|.::.:::...|.||..|:..:|.::|::||.|.|:|:||.:|:::...:.....|.
 Worm    45 RWYIMLVFAFLYLIIIAAGIIGNSCVILAITRNKSLQTVPNLFILSLSCSDIVVCCTSATITPIT 109

  Fly   144 MLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVLIWAL 208
            ....:|.||...|.|..|:|.:::..|.|||.|||.||||.|..|:::..:..:...::.:|.|.
 Worm   110 AFKKEWIFGEALCRIAPFIAGISLCFSTFTLTAISIDRYILIRFPMRKPITHYQAVGVIAIICAF 174

  Fly   209 SCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPT------SMADYAYNLIILVLTYGIPM 267
            :..:::|.:....:       |:....|      |:|.|      ......|...::.|...||:
 Worm   175 AATITSPIMFKQKL-------GEFENFC------GQYCTENWGANESQRKIYGAALMFLQLVIPL 226

  Fly   268 IVMLICYSLM------GRVLWGSRSIG------ENTDRQMESMKSKRKVVRMFIAIVSIFAICWL 320
            .:::|.|:.:      ..:|.|::...      |.:|:|..::|.:::..||.|.:|..||..|:
 Worm   227 TIIIISYTAISLKIGQSMILKGAKKQKTDNWEMELSDQQRIAVKRRQRTNRMLIGMVVAFACSWI 291

  Fly   321 ---PYHLFFIYAYHNNQVASTKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCC 382
               .:::...|.|....:.:.:|:  ..:..:.:||::.:.|||:|..:|.:.|..|   |....
 Worm   292 WSVTFNILRDYEYLPELIKTQEYI--FGIATHCIAMTSTVWNPLLYAVLNLQLRAAF---IDLMP 351

  Fly   383 VGLTRH----------RFDSPKSRLTNKNSSNRHTRGGYTVAHSLPNSSPPTTQTLLAVLAQTLT 437
            ..|.||          ..:.|...:|||..|.                   .|:|:.|....|..
 Worm   352 HWLRRHLNLEGDNSSPLLNHPTMTITNKYGST-------------------ATKTVKATYINTSN 397

  Fly   438 -QPKPQTQLLLSHHSPHPTQPSAAETKSQWKRSTMETQIQQAPVTSSCREQRSAQQQQ 494
             ||...|.|:   ....|..||.....|..|:|.|...:.|         :|:|::::
 Worm   398 GQPYVSTSLV---GKVQPEAPSFKFNGSGRKKSAMMRILVQ---------KRNAEEEE 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	74/310 (24%)
		TM helix 1	85..111	CDD:320512	6/25 (24%)
		TM helix 2	118..144	CDD:320512	7/25 (28%)
		TM helix 3	156..186	CDD:320512	15/29 (52%)
		TM helix 4	197..218	CDD:320512	3/20 (15%)
		TM helix 5	251..280	CDD:320512	6/34 (18%)
		TM helix 6	299..329	CDD:320512	8/32 (25%)
		TM helix 7	342..367	CDD:320512	6/24 (25%)
npr-4	NP_001300304.1	7tmA_NPYR-like	50..346	CDD:320331	74/310 (24%)
		TM helix 1	51..77	CDD:320331	6/25 (24%)
		TM helix 2	84..109	CDD:320331	6/24 (25%)
		TM helix 3	122..152	CDD:320331	15/29 (52%)
		TM helix 4	163..184	CDD:320331	3/20 (15%)
		TM helix 5	210..239	CDD:320331	6/28 (21%)
		TM helix 6	270..300	CDD:320331	8/29 (28%)
		TM helix 7	314..339	CDD:320331	7/26 (27%)