Protein Alignment TkR86C and Npy6r

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_035065.1
• Gene: Npy6r / 18169
• MGIID: 1098590
• Length: 371
• Species: Mus musculus
• Alignment Length: 383
• Identity: 102/383 - (26%)
• Similarity: 183/383 - (47%)
• Gaps: 44/383 - (11%)

  Fly    50 NRDNLESINEAKDFLTECLFPSPTRPYELPWEQKTIWAIIFGLMMFVAIAGN-GIVLWIVTGHRS 113
            |:.:.:|.|.|..:...|         :.|:....:..|.:.:::.:.|.|| .:::.|....|.
Mouse    11 NKTSGKSNNSAFFYFESC---------QPPFLAILLLLIAYTVILIMGIFGNLSLIIIIFKKQRE 66

  Fly   114 MRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAIS 178
            .:.|||..:.|||::|:|:..:...|..|:.|...|.||:..|.:.::|.:|:||.|:|:||.|:
Mouse    67 AQNVTNILIANLSLSDILVCVMCIPFTVIYTLMDHWVFGNTMCKLTSYVQSVSVSVSIFSLVLIA 131

  Fly   179 FDRYIAIVHP--LKRRTSRRKVRIILVLIWALSCVLSAPCLLYSSIMTKHYYNGKSRT------- 234
            .:||..||:|  .|.|.:.....||  |||.:|..||.|..|...:..:.::|....|
Mouse   132 IERYQLIVNPRGWKPRVAHAYWGII--LIWLISLTLSIPLFLSYHLTNEPFHNLSLPTDIYTHQV 194

  Fly   235 VCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLMGRVLWGSRSIGENTDRQMES-- 297
            .|..:|     |:.:....::..:.:|.|.:|:..:||||.   :::...|......||:.|:
Mouse   195 ACVEIW-----PSKLNQLLFSTSLFMLQYFVPLGFILICYL---KIVLCLRKRTRQVDRRKENKS 251

  Fly   298 -MKSKRKVVRMFIAIVSIFAICWLPYHLF-FIYAYHNNQVASTKYVQHMYLGFYWLAMSNAMVNP 360
             :...::|..|.|:||..|..||||.::| .|:.:::..:.|..: ..:::..:.:||.:..:||
Mouse   252 RLNENKRVNVMLISIVVTFGACWLPLNIFNVIFDWYHEMLMSCHH-DLVFVVCHLIAMVSTCINP 315

  Fly   361 LIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPKSRLTNKNSSNRHT---RGGYTVAH 415
            |.|.::||.|:.....:|..|..|       .|:....|...|..||   :|...:||
Mouse   316 LFYGFLNKNFQKDLMMLIHHCWCG-------EPQESYENIAMSTMHTDESKGSLKLAH 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	85/303 (28%)
		TM helix 1	85..111	CDD:320512	5/26 (19%)
		TM helix 2	118..144	CDD:320512	9/25 (36%)
		TM helix 3	156..186	CDD:320512	12/29 (41%)
		TM helix 4	197..218	CDD:320512	9/20 (45%)
		TM helix 5	251..280	CDD:320512	7/28 (25%)
		TM helix 6	299..329	CDD:320512	12/30 (40%)
		TM helix 7	342..367	CDD:320512	6/24 (25%)
Npy6r	NP_035065.1	7tm_GPCRs	42..329	CDD:475119	84/297 (28%)
		TM helix 1	42..63	CDD:320518	4/20 (20%)
		TM helix 2	72..94	CDD:320518	7/21 (33%)
		TM helix 3	110..132	CDD:320518	9/21 (43%)
		TM helix 4	153..169	CDD:320518	8/17 (47%)
		TM helix 5	207..230	CDD:320518	6/22 (27%)
		TM helix 6	260..282	CDD:320518	10/21 (48%)
		TM helix 7	297..322	CDD:320518	6/24 (25%)