DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and pcdr-1

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_510580.1	Gene:	pcdr-1 / 181656	WormBaseID:	WBGene00010329	Length:	318	Species:	Caenorhabditis elegans

Alignment Length:	310	Identity:	71/310 - (22%)
Similarity:	131/310 - (42%)	Gaps:	37/310 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 LMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFG---S 153
            |::||....|   :.::.....:..|...:|::||:||||.:......:....|..:|..|   |
Worm    26 LLLFVTSILN---ITVIAFTPDLSDVIGCYLISLSVADLLTAIFVIPLSIYSTLEGNWRIGGDNS 87

  Fly   154 IYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLK-RRTSRRKVRIILVLIWALSCVLSAPCL 217
            |.|....::......::|:|...|..|||.|::.|.: ...|..:.:..:|..|..|.:|..| :
Worm    88 IICKSAAYLQIALFCSTVYTFAWICIDRYSAMMKPSRYSEQSLTRCKCWIVFSWLTSMLLCCP-I 151

  Fly   218 LYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLMGRVLW 282
            :.:.:....|.:.:   :|.:.|        .|..||::.:|:|.: :|.:|.:.   ..|..:|
Worm   152 IVARMQVVFYPDAQ---LCVLDW--------SATSAYSVTLLLLVF-VPTLVTVF---NTGWKIW 201

  Fly   283 GS-RSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLF----FIYAYHNNQVASTKYVQ 342
            .: |:.....|.|...:::....|......|:.| :.|||....    .|:...:..::...:.
Worm   202 SAMRNPAALDDSQRMLVETDPNFVLTGFLFVTFF-LSWLPLITLKVCELIWGPFDMDLSMLTFF- 264

  Fly   343 HMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICC--CCVGLTRHRF 390
                 |.|||:|......|||.:.|.:||..|...|.|  ||...:|:.:
Worm   265 -----FVWLAVSGPCCKFLIYMFTNHQFRRSFLSYISCSMCCSSRSRYEY 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	66/292 (23%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	57/271 (21%)
pcdr-1	NP_510580.1	7tm_classA_rhodopsin-like	17..284	CDD:381740	62/283 (22%)
		TM helix 1	17..41	CDD:381740	4/17 (24%)
		TM helix 2	50..72	CDD:381740	7/21 (33%)
		TM helix 3	91..113	CDD:381740	3/21 (14%)
		TM helix 4	135..151	CDD:381740	5/16 (31%)
		TM helix 5	175..198	CDD:381740	6/26 (23%)
		TM helix 6	224..246	CDD:381740	6/22 (27%)
		TM helix 7	259..284	CDD:381740	8/30 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910