DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and Ptgdr2

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_034092.1	Gene:	Ptgdr2 / 14764	MGIID:	1330275	Length:	382	Species:	Mus musculus

Alignment Length:	380	Identity:	89/380 - (23%)
Similarity:	165/380 - (43%)	Gaps:	68/380 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 IIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFG 152
            ::.||...:.:..||::|::| |.|..:||...::|:|:::|||.::....|.:...:...|..|
Mouse    36 LLHGLASLLGLVENGLILFVV-GCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELG 99

  Fly   153 SIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPL---KRRTSRRKVRIILVLIWALSCVLSA 214
            :.:|.:::.|..:.:..|.|.|.|||.||.:.:|.|:   ..||.....|:.|:| |||:.:.:.
Mouse   100 TTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLML-WALAVLNTI 163

  Fly   215 PCLLYSSIMTK------HYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIIL---VLTYGIPMIVM 270
            |..::...:.:      .|||       .::|..|....:..||....:.:   :|.:.:|:.::
Mouse   164 PYFVFRDTIPRLDGRIMCYYN-------LLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAII 221

  Fly   271 LICYSLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQV 335
                        .|..:..:........:...:.||:..|||..|.:||.|||:|.:.....:.|
Mouse   222 ------------ASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSV 274

  Fly   336 ASTKYVQHMYLGFYW-LAMSNAMVNPLIY--------YWMNKRFRMYFQRIICCCCVGLTRHRFD 391
            .:.:.:....|.|.. ||..|::||||:|        |.:.:..|...:.::.          .|
Mouse   275 TTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLV----------ED 329

  Fly   392 SPKSRLTNKNSSNRHTRGGYTVAHSLPNSSPPTTQTLLAVLAQTLTQPKPQTQLL 446
            |.:|             ||........:|:.....|||  ||..:.|.:| |:|:
Mouse   330 SDQS-------------GGLRNRRRRASSTATPASTLL--LADRIPQLRP-TRLI 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	73/304 (24%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	69/275 (25%)
Ptgdr2	NP_034092.1	7tm_GPCRs	32..314	CDD:391938	73/298 (24%)
		TM helix 1	34..58	CDD:341315	6/22 (27%)
		TM helix 2	66..87	CDD:341315	5/20 (25%)
		TM helix 3	104..126	CDD:341315	6/21 (29%)
		TM helix 4	149..165	CDD:341315	6/16 (38%)
		TM helix 5	203..226	CDD:341315	3/34 (9%)
		TM helix 6	241..266	CDD:341315	12/24 (50%)
		TM helix 7	282..307	CDD:341315	10/24 (42%)
		Involved in the recycling of CRTH2. /evidence=ECO:0000250	329..332		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000