DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and f2rl3

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_002934417.1	Gene:	f2rl3 / 100491210	XenbaseID:	XB-GENE-940203	Length:	391	Species:	Xenopus tropicalis

Alignment Length:	395	Identity:	103/395 - (26%)
Similarity:	180/395 - (45%)	Gaps:	80/395 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 EVVSLLSSIIDNRDNL----ESINEAKDFLTECLFPSPTRPYELPWEQKTIWAIIFGLMMFVAIA 99
            |::|.     :||..|    .||:..|..:|..:.||                 |:.|:..|.:.
Frog    56 EIISK-----NNRTYLCISPSSIDHLKSPITVLVIPS-----------------IYTLVFLVGLP 98

  Fly   100 GNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLM-SSLNCVFNFIFMLNSDWPFGSIYCTI--NNF 161
            .|.:.||:: ..|..:..:..||:||::||||: .:|....::.| |.:||.||...|.:  :.|
Frog    99 ANVVALWVL-ATRVKKMTSTVFLINLAVADLLLIVTLPFKISYYF-LGNDWIFGETLCRVVTSFF 161

  Fly   162 VANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVLIWALSCVLSAPCLLYSSIMTKH 226
            .||  :..||..|::||.|||:|:|||...||.|.|  ...:.:..:|.:::|..:|..:.|.:.
Frog   162 YAN--IYCSVLLLMSISVDRYMAVVHPFFSRTFRSK--NFAIFMCTISWMIAALSILPLAAMRQS 222

  Fly   227 Y-YNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLMGRVLWGSRSIGEN 290
            | .:....|:|....|.....|.:  :.|.|.::||.:.:|:.:::.||..:.|||.      .|
Frog   223 YPLSTTDLTLCHDGLPRNEQVTYL--FYYFLCLVVLGFLLPLSIIIFCYVSVIRVLM------RN 279

  Fly   291 TDRQMESMKSKRKVVRMFIAIVSIFAICWL-PYHLFFIYAYHNNQVASTKYVQHMYLGFY----- 349
            ..:...::|        .||:|.:..|..| |.::..:..|      |.::: |.|...|
Frog   280 EGKYGYALK--------LIALVLVIVIVLLTPSNVVLLIHY------SERFL-HTYGDLYSVYMV 329

  Fly   350 WLAMS--NAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHRF-DSPKSRLTNKNSSNRHTRGGY 411
            .||:|  |:.|:|.:||:::..||   :::         |.:| ...|..:|:..:|........
Frog   330 CLAISSLNSCVDPFVYYYVSDEFR---EKV---------RQQFRKRSKLSITSLKTSKEVLPATT 382

  Fly   412 TVAHS 416
            |.:||
Frog   383 TTSHS 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	83/295 (28%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	77/274 (28%)
f2rl3	XP_002934417.1	7tmA_PAR4	83..356	CDD:320494	86/321 (27%)
		TM helix 1	83..110	CDD:320494	8/44 (18%)
		TM helix 2	116..141	CDD:320494	9/24 (38%)
		TM helix 3	154..184	CDD:320494	13/31 (42%)
		TM helix 4	196..218	CDD:320494	3/21 (14%)
		TM helix 5	246..275	CDD:320494	7/30 (23%)
		TM helix 6	281..311	CDD:320494	7/37 (19%)
		TM helix 7	324..349	CDD:320494	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910