Protein Alignment TkR86C and oprk1

DIOPT Version :10

• Sequence 1: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_001305708.1
• Gene: oprk1 / 100489465
• XenbaseID: XB-GENE-1011503
• Length: 420
• Species: Xenopus tropicalis
• Alignment Length: 431
• Identity: 112/431 - (25%)
• Similarity: 194/431 - (45%)
• Gaps: 92/431 - (21%)

  Fly    49 DNRDNLES-----INEAKDFLTECLFPSPTRPYELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIV 108
            |:.||:.:     :||......     |||        ...|...::.::..|.:.||.:|::::
 Frog    50 DDHDNVSAYPDLPLNEGNHTSI-----SPT--------ISVIITAVYSMVFVVGLVGNALVMFVI 101

  Fly   109 TGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFT 173
            ..:..|:|.||.::.||::||.|:::.....:..|::|| ||||.:.|.|...:....:.||:||
 Frog   102 IRYTKMKTATNIYIFNLALADALVTTTMPFQSTSFLMNS-WPFGDVLCKIVVSIDYYNMFTSIFT 165

  Fly   174 LVAISFDRYIAIVHPLKRRTSRR--KVRIILVLIWALSCVLSAPCLLYSSIMTKHYYNGKSRTVC 236
            |..:|.|||||:.||:|....|.  |.:.|.:.||.||..:....::...  ||   .....|.|
 Frog   166 LTMMSVDRYIAVCHPVKALDFRTPLKAKCINICIWMLSSSVGISAIVLGG--TK---ISDGSTEC 225

  Fly   237 FMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLM------GRVLWGSRSIGENTDRQM 295
            .:.:|...:   ..|....:.:.:..:.||:.::.|||:||      .|:|.|||
 Frog   226 ALQFPTHYW---YWDTVMKMCVFIFAFIIPVFIITICYTLMILRLKSVRLLSGSR---------- 277

  Fly   296 ESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQVASTKYVQHMY----LGFYWLAMSNA 356
            |..::.|::.|:.:.:|::|.:||.|.|:|.:.....:...|...|...|    ||:     :|:
 Frog   278 EKDRNLRRITRLVLVVVAVFIVCWTPIHIFVLVEALVDVPQSIAVVSIYYFCIALGY-----TNS 337

  Fly   357 MVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHRFD-SPKSRLTN---KNSSNRHTRGGYTVAHSL 417
            .:||::|.::::.|:..|:..    |.. ::||.| .|.||:.|   ..:.|||
 Frog   338 SLNPILYAFLDENFKRCFKDF----CFP-SKHRLDRQPNSRVGNTVQDPACNRH----------- 386

  Fly   418 PNSSPPTTQTLLAVLAQTLTQPKPQTQLLLSHHSPHPTQPS 458
             .|..|..   |||...:||              ||..:|:
 Frog   387 -GSQKPVX---LAVEMTSLT--------------PHGREPN 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	82/301 (27%)
		TM helix 1	85..111	CDD:320512	5/25 (20%)
		TM helix 2	118..144	CDD:320512	7/25 (28%)
		TM helix 3	156..186	CDD:320512	13/29 (45%)
		TM helix 4	197..218	CDD:320512	6/20 (30%)
		TM helix 5	251..280	CDD:320512	8/34 (24%)
		TM helix 6	299..329	CDD:320512	9/29 (31%)
		TM helix 7	342..367	CDD:320512	7/28 (25%)
oprk1	NP_001305708.1	7tmA_Kappa_opioid_R	77..355	CDD:320219	82/301 (27%)
		TM helix 1	78..104	CDD:320219	5/25 (20%)
		TM helix 2	111..137	CDD:320219	7/25 (28%)
		TM helix 3	148..178	CDD:320219	13/29 (45%)
		TM helix 4	190..212	CDD:320219	6/21 (29%)
		TM helix 5	237..266	CDD:320219	8/28 (29%)
		TM helix 6	281..311	CDD:320219	9/29 (31%)
		TM helix 7	323..348	CDD:320219	8/29 (28%)
		YihI	<362..>408	CDD:470104	19/74 (26%)