DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TkR86C and tacr1

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001106489.1	Gene:	tacr1 / 100127678	XenbaseID:	XB-GENE-5835469	Length:	407	Species:	Xenopus tropicalis

Alignment Length:	311	Identity:	119/311 - (38%)
Similarity:	189/311 - (60%)	Gaps:	16/311 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 PYELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVF 139
            |:..|..|..:|:|.:.:::.|::.||.||:||:..|:.|||||||||:||:.|:..||:.|.|.
Frog    24 PFLQPAWQIALWSIAYSIIVIVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVI 88

  Fly   140 NFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVL 204
            ||.:.:::.|.:|.|||..:||.....|.:|::::.||:.|||:||:||||.|.|....||::.:
Frog    89 NFTYAIHNHWYYGLIYCKFHNFFPISAVFSSIYSMTAIALDRYMAIIHPLKPRLSATATRIVIAV 153

  Fly   205 IWALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIV 269
            ||..:..|:.|...::::...     ..|.||:|.||:..  ....:..|.:::..|.|.:|::|
Frog   154 IWGFAFALAFPQGYFATVEPT-----PDRVVCYMEWPESE--NRKFEKVYQVLLFGLIYFLPLLV 211

  Fly   270 MLICYSLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNNQ 334
            :...|:.:|..||.|...|:::||..|.:.:|||||:|.|.:|..|||||||||::|:.     |
Frog   212 IGCSYTFIGMTLWASEIPGDSSDRYHEQVVAKRKVVKMMIVVVCTFAICWLPYHIYFLL-----Q 271

  Fly   335 V----ASTKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCC 381
            :    .|.|:.|.:|||..||.||:.|.||:||..:|.|||:.|:.:...|
Frog   272 LFLPDESQKFYQQLYLGIMWLGMSSTMYNPIIYCCLNDRFRIGFKHVFRWC 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	113/287 (39%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	105/266 (39%)
tacr1	NP_001106489.1	7tmA_NK1R	33..315	CDD:320668	114/293 (39%)
		TM helix 1	34..60	CDD:320668	9/25 (36%)
		TM helix 2	67..93	CDD:320668	14/25 (56%)
		TM helix 3	105..135	CDD:320668	11/29 (38%)
		TM helix 4	146..167	CDD:320668	6/20 (30%)
		TM helix 5	193..222	CDD:320668	7/28 (25%)
		TM helix 6	241..271	CDD:320668	18/34 (53%)
		TM helix 7	283..308	CDD:320668	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	246	1.000	Domainoid score	I2128
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314830at33208
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	1	1.000	-	-		mtm9492
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920