DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR86C and p2ry1

DIOPT Version :9

Sequence 1:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001096222.1	Gene:	p2ry1 / 100124773	XenbaseID:	XB-GENE-1000145	Length:	361	Species:	Xenopus tropicalis

Alignment Length:	368	Identity:	89/368 - (24%)
Similarity:	162/368 - (44%)	Gaps:	73/368 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 TEVVSLLSSIID-NRDNLESINEAKDFLTEC-LFPSPTRPYELPWEQKTIWAIIFGLMMFVAIAG 100
            |||  .||:::: .:..|.:...:...:|:| |..:..:.|.||        .::.::......|
Frog     2 TEV--FLSALLNVTQSTLLASGSSAGNVTKCSLTKTGFQFYYLP--------AVYIVVCITGFIG 56

  Fly   101 NGIVLWIVTGHRSMRTVTNYFLLNLSIADLL-MSSLNCVFNFIFMLNSDWPFGSIYCTINNFVAN 164
            |.:.:|:...|....:..:.::.||::||.| :.||..:. |.:...:||.||...|.:..|:.:
Frog    57 NSVAIWMFIFHMKPWSSISVYMFNLALADFLYVLSLPALI-FYYFNKTDWIFGDALCKLQRFIFH 120

  Fly   165 VTVSTSVFTLVAISFDRYIAIVHPLKR--RTSRRKVRIILVLIWALSCVLSAPCLLYSSIMTKHY 227
            |.:..|:..|..||..||..:|||||.  |..::....|..|:|.:.....:|.|.:|....:
Frog   121 VNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNSIYISALVWFIVIAGISPILFFSGTGIR-- 183

  Fly   228 YNGKSRTV-CFMMWPDGRYPTSMADY-----AYNLIILVLTYGIPMIVMLICYSLMGRVLWGSRS 286
               |::|: ||        .||..:|     .|::...|..:.||.|::|.||.|:.|.|
Frog   184 ---KNKTITCF--------DTSSDEYLRSYFIYSMCTTVFGFCIPFILILGCYGLIVRAL----- 232

  Fly   287 IGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLF------------------FIYAYHNN 333
                ..:.|.:...::|.:.:.|.::::||:.:||:|:.                  |     |:
Frog   233 ----IYKDMNNAPLRKKSIYLVIIVLTVFAVSYLPFHVMKNLNLRARLDFQSPEMCNF-----ND 288

  Fly   334 QVASTKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQR 376
            :|.:|..|..      .||..|:.|:|::|:.....||....|
Frog   289 RVYATYQVTR------GLASLNSCVDPILYFLAGDTFRRKLSR 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	76/310 (25%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	73/289 (25%)
p2ry1	NP_001096222.1	7tmA_P2Y1	40..323	CDD:341350	79/324 (24%)
		TM helix 1	40..67	CDD:341350	6/34 (18%)
		TM helix 2	74..99	CDD:341350	8/25 (32%)
		TM helix 3	112..142	CDD:341350	9/29 (31%)
		TM helix 4	154..176	CDD:341350	4/21 (19%)
		TM helix 5	202..231	CDD:341350	9/28 (32%)
		TM helix 6	241..271	CDD:341350	7/29 (24%)
		TM helix 7	291..316	CDD:341350	8/30 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910