DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pug and folD

DIOPT Version :9

Sequence 1:	NP_001014614.1	Gene:	pug / 41279	FlyBaseID:	FBgn0020385	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_415062.1	Gene:	folD / 945221	ECOCYCID:	EG10328	Length:	288	Species:	Escherichia coli

Alignment Length:	291	Identity:	119/291 - (40%)
Similarity:	170/291 - (58%)	Gaps:	12/291 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 AKIISGTAVAKSIREELRNEVTA-MSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEIGIDA 101
            ||||.|..:|:.:|.|:..:|.| ::..|.  .|||.:|.||....|.:|:..|.||..|:|..:
E. coli     3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLR--APGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65

  Fly   102 AHVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTVNE 166
            ....||.:.:|.|||:.|:.||.|..:.||:||:||...  ||:.::.:.:.|:|||||.|..|.
E. coli    66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAG--IDNVKVLERIHPDKDVDGFHPYNV 128

  Fly   167 GRLAIGDLGGFLPCTPWGCLELIRRSGVEIAGARAVVLGRSKIVGTPAAELLKWANATVTVCHSK 231
            |||. .......||||.|.:.|:.|..::..|..|||:|.|.|||.|.:..|..|..|.||.|..
E. coli   129 GRLC-QRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRF 192

  Fly   232 TRNLEEITRSADILVVGIGVAEMVKGSWIKPGAVVIDCGINVKPDASKASGSKLVGDVDYAEALQ 296
            |:||.....:||:|:|.:|....:.|.|||.||:|||.|||      :....|:||||.:.:|.:
E. coli   193 TKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGIN------RLENGKVVGDVVFEDAAK 251

  Fly   297 VAGHLTPVPGGVGPMTVAMLMKNTVRSAARF 327
            .|.::|||||||||||||.|::||:::...:
E. coli   252 RASYITPVPGGVGPMTVATLIENTLQACVEY 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pug	NP_001014614.1	FolD	39..330	CDD:223268	118/290 (41%)
		THF_DHG_CYH	40..159	CDD:279147	43/119 (36%)
		NAD_bind_m-THF_DH_Cyclohyd	154..324	CDD:133448	77/169 (46%)
		FTHFS	350..968	CDD:279592
folD	NP_415062.1	PRK10792	1..285	CDD:236760	119/291 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	1	1.100	-	-	O	PTHR48099
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	3	2.910