DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pug and MTD1

DIOPT Version :9

Sequence 1:	NP_001014614.1	Gene:	pug / 41279	FlyBaseID:	FBgn0020385	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_013006.3	Gene:	MTD1 / 853955	SGDID:	S000001788	Length:	320	Species:	Saccharomyces cerevisiae

Alignment Length:	338	Identity:	82/338 - (24%)
Similarity:	128/338 - (37%)	Gaps:	88/338 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEIGIDAAH 103
            :.|..:.||::...|:.|.|....|......|.|..........:.:|.....|.:..:|.   .
Yeast     6 RTILASKVAETFNTEIINNVEEYKKTHNGQGPLLVGFLANNDPAAKMYATWTQKTSESMGF---R 67

  Fly   104 VQLPRSITEVELLDK-INDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTV--- 164
            ..| |.|.:.:.|:: |...|.|..|:||:|..|:..:.  ....:...|..||||:||:.|
Yeast    68 YDL-RVIEDKDFLEEAIIQANGDDSVNGIMVYFPVFGNA--QDQYLQQVVCKEKDVEGLNHVYYQ 129

  Fly   165 ----------NEGRLAIGDLGGFLPCTPWGCLELIR---------RSGVEIAGARAVVLGRSKIV 210
                      .|.||.     ..|||||...::::.         ..|..:.|.:.:|:.||:||
Yeast   130 NLYHNVRYLDKENRLK-----SILPCTPLAIVKILEFLKIYNNLLPEGNRLYGKKCIVINRSEIV 189

  Fly   211 GTPAAELLKWANATVTVCHSKTRNLEEITR---------------------------SADILVVG 248
            |.|.|.||  ||...||......|:::.||                           .:|:::.|
Yeast   190 GRPLAALL--ANDGATVYSVDVNNIQKFTRGESLKLNKHHVEDLGEYSEDLLKKCSLDSDVVITG 252

  Fly   249 IGVAEMVK--GSWIKPGAVVID--CGINVKPDASKASGSKLVGDVDYAEALQVAGHLTPVPGGVG 309
            : .:|..|  ..:||.|||.|:  |..|...|..                 :.|....|:.|.|
Yeast   253 V-PSENYKFPTEYIKEGAVCINFACTKNFSDDVK-----------------EKASLYVPMTGKV- 298

  Fly   310 PMTVAMLMKNTVR 322
              |:|||::|.:|
Yeast   299 --TIAMLLRNMLR 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pug	NP_001014614.1	FolD	39..330	CDD:223268	82/338 (24%)
		THF_DHG_CYH	40..159	CDD:279147	28/119 (24%)
		NAD_bind_m-THF_DH_Cyclohyd	154..324	CDD:133448	57/222 (26%)
		FTHFS	350..968	CDD:279592
MTD1	NP_013006.3	THF_DHG_CYH	8..121	CDD:395619	28/118 (24%)
MTD1	NP_013006.3	NAD_bind_m-THF_DH	116..316	CDD:133447	57/222 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.875	Normalized mean entropy	S317
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860