DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pug and THFS

DIOPT Version :9

Sequence 1:	NP_001014614.1	Gene:	pug / 41279	FlyBaseID:	FBgn0020385	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_564571.1	Gene:	THFS / 841470	AraportID:	AT1G50480	Length:	634	Species:	Arabidopsis thaliana

Alignment Length:	630	Identity:	372/630 - (59%)
Similarity:	464/630 - (73%)	Gaps:	3/630 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 TLPLKPQRPVPSDIVIARAQKPKDIAVLAKEIGLEAREVSLYGNKKAKISLSVLERLKDKEVGHY 404
            |..|:...|||:||.||.:.:|..|:.:||::.:......|||..|||:.||..:.|:.:|.|:|
plant     5 TRKLEVVSPVPADIDIANSVEPLHISEIAKDLNINPLHYDLYGKYKAKVLLSAFDELQGQEDGYY 69

  Fly   405 VVVAGMTPTPLGEGKTTTLMGLVQALGAHKLRNTMAALRQPSQGPTFGIKGGAAGGGYAQVIPME 469
            |||.|:|||||||||:||.:||.|||||:..:..:..|||||||||||||||||||||:|||||:
plant    70 VVVGGITPTPLGEGKSTTTVGLCQALGAYLDKKVVTCLRQPSQGPTFGIKGGAAGGGYSQVIPMD 134

  Fly   470 EFNLHLTGDIHAVSAANNLLAAQLDTRIFHENTQKDKALYDRLVPAIK-GQRKFSPIQLRRLQKL 533
            ||||||||||||::|:||||||.:|||||||.:|.||||::||.|..| |:|.||.|..|||.||
plant   135 EFNLHLTGDIHAITASNNLLAAAIDTRIFHETSQSDKALFNRLCPPNKEGKRSFSDIMFRRLTKL 199

  Fly   534 GITKTDPDTLTADEYGPFARLDIDPDTIMWERVVDINDRYLRTITVGQSPTEKGISRETRFSISV 598
            ||:||.|:.||.:|...||||||||.:|.|.||:|:|||:||.||:||.|.|||::|||.|.|||
plant   200 GISKTSPEELTPEEIKKFARLDIDPASITWRRVMDVNDRFLRKITIGQGPEEKGMTRETGFDISV 264

  Fly   599 ASEIMAVLALSRSLEDMKQRLADMVVAFDKRGKPVTADDLGVTGALAVLLKDALEPNLMQSLEGT 663
            ||||||||||:.||.||::||..||:...|.|.|:|||||||.|||.||:|||:.|.|||:||||
plant   265 ASEIMAVLALTTSLGDMRERLGKMVIGNSKAGDPITADDLGVGGALTVLMKDAINPTLMQTLEGT 329

  Fly   664 PVLVHAGPFANIAHGCNSIIADEVGLKLVGKNGFVCTEAGFGSDIGMEKFCNIKCRTSGRKPNAM 728
            |||||||||||||||.:||:||::.|||||..|||.||||||||||.|||.|||||.||..|...
plant   330 PVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVTEAGFGSDIGTEKFMNIKCRYSGLTPQCA 394

  Fly   729 VLVATVRAIKMHGGGAPVTPGAPLNKQYTEENLELVQKGLPNLLQHIENGKAFGMPVVVSLNAHS 793
            ::||||||:||||||..|..|.||::.|..||:.||:.|..||.:||.|.||:|:.|:|::|..:
plant   395 IVVATVRALKMHGGGPDVVAGRPLDRAYVSENVSLVEAGCVNLAKHISNTKAYGVNVIVAVNMFA 459

  Fly   794 ADTPAEHELVKKAALEAGAFAAVVSTHWADGGAGAVQLADAVIKACEQGNQ-FRLLYDLELPLVD 857
            .||.||...|:|.:::||||.|||.:|.|..|.|||.|..||.|||:...| .|.||.|::.:.|
plant   460 TDTEAELNAVRKFSMDAGAFDAVVCSHHAHSGKGAVDLGIAVEKACQNITQPLRFLYPLDIGIKD 524

  Fly   858 KMNKIATTMYGAGKVVLSPAAEEKVKRLTDAGFGNLPICMSKVSGSFTGDAKIKGAPKGFTLDVE 922
            |:..||.: |||..|..|..||::::..|..||.||||||||...||:.||..||||.||.|.:.
plant   525 KIEAIAKS-YGASGVEYSDQAEKQIEMYTQQGFSNLPICMSKTQYSFSHDASKKGAPSGFVLPIR 588

  Fly   923 DVYVSAGAGFVVAMCGEVTKMPGLPTRPAIYDIDLNTETGEIEGL 967
            ||..|.||||:..:.|.::.||||||||..|:||::||||::.||
plant   589 DVRGSIGAGFIYPLVGTMSTMPGLPTRPCFYEIDIDTETGKVRGL 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pug	NP_001014614.1	FolD	39..330	CDD:223268
		THF_DHG_CYH	40..159	CDD:279147
		NAD_bind_m-THF_DH_Cyclohyd	154..324	CDD:133448
		FTHFS	350..968	CDD:279592	368/620 (59%)
THFS	NP_564571.1	PLN02759	1..634	CDD:178359	372/630 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	703	1.000	Domainoid score	I15
eggNOG	1	0.900	-	-		E1_COG2759
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55940
Inparanoid	1	1.050	725	1.000	Inparanoid score	I117
OMA	1	1.010	-	-		QHG53867
OrthoDB	1	1.010	-	-		D690393at2759
OrthoFinder	1	1.000	-	-		FOG0001266
OrthoInspector	1	1.000	-	-		oto3950
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X878
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.740