DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pug and mthfd1a

DIOPT Version :9

Sequence 1:NP_001014614.1 Gene:pug / 41279 FlyBaseID:FBgn0020385 Length:968 Species:Drosophila melanogaster
Sequence 2:XP_021329049.1 Gene:mthfd1a / 567587 ZFINID:ZDB-GENE-041001-127 Length:919 Species:Danio rerio


Alignment Length:925 Identity:450/925 - (48%)
Similarity:611/925 - (66%) Gaps:32/925 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 AKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEIGIDAA 102
            |.::||...::.:::.|:.||..|..|...|.|||.::|||.|||||:||.||:|||.||||:|.
Zfish    25 ATVVSGNKTSQQVKQRLKEEVEQMKSQFPGFRPGLVVLQVGDREDSNLYISMKLKAAAEIGINAN 89

  Fly   103 HVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTVNEG 167
            |::||.:.||.|:|..|..:||:|..||:|||:|||...||::.:||:||:||||||||.::|.|
Zfish    90 HIRLPETATENEVLRNIVAVNENPAFHGLIVQLPLDSINPINTEKITNAVAPEKDVDGLTSINAG 154

  Fly   168 RLAIGDLGG-FLPCTPWGCLELIRRSGVEIAGARAVVLGRSKIVGTPAAELLKWANATVTVCHSK 231
            :|:.||||. |:||||.||:|||.::||.:.|..|||:|||||||.|..:||.|::||||.||||
Zfish   155 KLSRGDLGDCFIPCTPNGCMELISQTGVSVMGKNAVVIGRSKIVGAPMHDLLLWSHATVTTCHSK 219

  Fly   232 TRNLEEITRSADILVVGIGVAEMVKGSWIKPGAVVIDCGINVKPDASKASGSKLVGDVDYAEALQ 296
            |.:|.|....|||||||.|.||||||.|:|.||||||||||..||.|||||.::||||.|..|.|
Zfish   220 TPDLAEQVGKADILVVGAGRAEMVKGEWVKEGAVVIDCGINHIPDESKASGKRVVGDVHYPSAKQ 284

  Fly   297 VAGHLTPVPGGVGPMTVAMLMKNTVRSAARFLERLAKSQWALQTLPLKPQRPVPSDIVIARAQKP 361
            .||.:||||||||||||||||||||.||.|||:.....:|.|.....:|..|.|||..|:.:.:.
Zfish   285 RAGFITPVPGGVGPMTVAMLMKNTVESAKRFLQTHTPGKWNLVYTKKRPHEPQPSDAAISSSCES 349

  Fly   362 KDIAVLAKEIGLEAREVSLYGNKKAKISLSVLERLKDKEVGHYVVVAGMTPTPLGEGKTTTLMGL 426
            |.:..||:|:||.:.||..||..:|||.|..|:|::.:..|.||||.|:|.:||||||.||.:||
Zfish   350 KPVVQLARELGLFSDEVESYGRSRAKIRLDALKRMEKQPNGKYVVVTGVTSSPLGEGKRTTALGL 414

  Fly   427 VQALGAHKLRNTMAALRQPSQGPTFGIKGGAAGGGYAQVIPMEEFNLHLTGDIHAVSAANNLLAA 491
            .||||||...|..|.:::.|....||.:|.|.||||:|:||:||.:|..:|....||||..|:..
Zfish   415 AQALGAHLNTNAFACVQKSSLETCFGARGPAVGGGYSQIIPLEEVSLQPSGQNELVSAAGRLVMD 479

  Fly   492 QLDTRIFHENTQKDKALYDRLVPAIKGQRKFSPIQLRRLQKLGITKTDPDTLTADEYGPFARLDI 556
            .:.....:|....:|||:|.|||..:|||..|..||.||:||.|.|:||.|||..|...|.||||
Zfish   480 TVKAYAHYETKLSEKALFDLLVPLREGQRCVSLAQLNRLKKLAIEKSDPLTLTEREIRRFIRLDI 544

  Fly   557 DPDTIMWERVVDINDRYLRTITVGQSPTEKGISRETRFSISVASEIMAVLALSRSLEDMKQRLAD 621
            |.|                      |.|:         |.|:.:|:||||:||.|.|:|:.|||:
Zfish   545 DTD----------------------SATD---------SFSLENEMMAVLSLSSSEEEMQHRLAN 578

  Fly   622 MVVAFDKRGKPVTADDLGVTGALAVLLKDALEPNLMQSLEGTPVLVHAGPFANIAHGCNSIIADE 686
            ::||.:|.|.|:|.:||.|:|.||:|||:||:|.|||::|||||.:|..|..|:|.|..||:||:
Zfish   579 IIVATNKSGDPITTEDLNVSGPLAMLLKEALKPVLMQTVEGTPVFLHTSPLVNVAQGGPSILADK 643

  Fly   687 VGLKLVGKNGFVCTEAGFGSDIGMEKFCNIKCRTSGRKPNAMVLVATVRAIKMHGGGAPVTPGAP 751
            :.||:||..|||.||:|.|:|:|:|||.||||..||.:|:.:|:|||:|.:||.||..|:..|.|
Zfish   644 MALKIVGSEGFVVTESGHGADVGLEKFFNIKCLYSGLQPDVLVMVATIRTLKMQGGAPPIQAGLP 708

  Fly   752 LNKQYTEENLELVQKGLPNLLQHIENGKAFGMPVVVSLNAHSADTPAEHELVKKAALEAGAFAAV 816
            |.|:|.:|||:.:::|..::.:.:|..:|||:||:|::|..|:||.||.|||...|.:||||.||
Zfish   709 LPKEYLQENLKQLERGCCHMRRQVEKAQAFGLPVIVAVNKFSSDTDAELELVCGQARQAGAFDAV 773

  Fly   817 VSTHWADGGAGAVQLADAVIKACEQGNQFRLLYDLELPLVDKMNKIATTMYGAGKVVLSPAAEEK 881
            ..:.|::|||||:.||:.|.:|.:....|:.||||:.|..||:..:|..|||...|.|||.|:||
Zfish   774 QCSSWSEGGAGALALAETVQRAAKLPACFKFLYDLQTPASDKLRTVAQKMYGLKDVKLSPKAKEK 838

  Fly   882 VKRLTDAGFGNLPICMSKVSGSFTGDAKIKGAPKGFTLDVEDVYVSAGAGFVVAMCGEVTKMPGL 946
            :...|..||.|||:|::|...|.:.|..:||:...|.|.:.|:..:|||||:..:.|........
Zfish   839 LALYTKQGFENLPVCIAKTPLSLSNDPMMKGSSTDFMLPITDIKANAGAGFLCCLTGSTNAEMDD 903

  Fly   947 PTRPAIYDIDLNTET 961
            |..|..:..:|.:::
Zfish   904 PMWPCFHGNNLYSDS 918

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pugNP_001014614.1 FolD 39..330 CDD:223268 176/291 (60%)
THF_DHG_CYH 40..159 CDD:279147 60/118 (51%)
NAD_bind_m-THF_DH_Cyclohyd 154..324 CDD:133448 115/170 (68%)
FTHFS 350..968 CDD:279592 269/612 (44%)
mthfd1aXP_021329049.1 FolD 26..315 CDD:223268 173/288 (60%)
FTHFS 353..897 CDD:238266 261/574 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 218 1.000 Domainoid score I2594
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53867
OrthoDB 1 1.010 - - D690393at2759
OrthoFinder 1 1.000 - - FOG0001266
OrthoInspector 1 1.000 - - otm26600
orthoMCL 1 0.900 - - OOG6_100216
Panther 1 1.100 - - O PTHR48099
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X878
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
98.930

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