DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pug and Nmdmc

DIOPT Version :9

Sequence 1:	NP_001014614.1	Gene:	pug / 41279	FlyBaseID:	FBgn0020385	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_476929.1	Gene:	Nmdmc / 47895	FlyBaseID:	FBgn0010222	Length:	309	Species:	Drosophila melanogaster

Alignment Length:	300	Identity:	137/300 - (45%)
Similarity:	182/300 - (60%)	Gaps:	17/300 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 AKIISGTAVAKSIREELRNEVTAMSKQLADF-VPGLRIVQVGGREDSNVYIRMKIKAATEIGIDA 101
            |:||.|.|:|:.:|.:|.:|:..|  :.|.: .|.|..|.||....|..|:..|:.|..|:||.:
  Fly     8 AQIIDGKAIAQEVRTQLAHELKGM--EAAGYPKPHLTAVIVGEDPASEKYVANKMVACREVGISS 70

  Fly   102 AHVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTVNE 166
            ...:||.|.|:.|||..|.|||:||:|.||:||:|:  ...|:...|.:||..:|||||.:.||.
  Fly    71 ETKRLPASTTQEELLQLIADLNKDPQVTGILVQLPV--PEHINERTICNAVDVDKDVDGFNEVNI 133

  Fly   167 GRLAIGDLGGFLPCTPWGCLELIRRSGVEIAGARAVVLGRSKIVGTPAAELL----KWA----NA 223
            ||.|: |:...:|.||.|...|:....:|..|..|||:||||.|..|.|.||    |:|    :|
  Fly   134 GRTAL-DMEANIPATPLGVKRLLEHMKIETLGRNAVVVGRSKNVSLPMAILLHADGKYATKAMDA 197

  Fly   224 TVTVCHSKT--RNLEEITRSADILVVGIGVAEMVKGSWIKPGAVVIDCGINVKPDASKASGSKLV 286
            |||:||..|  :.|....|.|||:||.:|...::....:||||.|||.|||...|.|... .|||
  Fly   198 TVTICHRYTPPKELARHCRQADIIVVAVGKPGLITKDMVKPGACVIDVGINRIKDESTGQ-FKLV 261

  Fly   287 GDVDYAEALQVAGHLTPVPGGVGPMTVAMLMKNTVRSAAR 326
            ||||:.|..|||||:||||||||||||||||.||:::|.:
  Fly   262 GDVDFEEVRQVAGHITPVPGGVGPMTVAMLMHNTLKAARK 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pug	NP_001014614.1	FolD	39..330	CDD:223268	136/298 (46%)
		THF_DHG_CYH	40..159	CDD:279147	47/119 (39%)
		NAD_bind_m-THF_DH_Cyclohyd	154..324	CDD:133448	90/179 (50%)
		FTHFS	350..968	CDD:279592
Nmdmc	NP_476929.1	FolD	9..304	CDD:223268	136/298 (46%)
		THF_DHG_CYH	10..126	CDD:279147	47/119 (39%)
		THF_DHG_CYH_C	129..303	CDD:280955	86/174 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464702
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41938at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	1	1.100	-	-	P	PTHR48099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850