DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pug and mthfd2l

DIOPT Version :9

Sequence 1:	NP_001014614.1	Gene:	pug / 41279	FlyBaseID:	FBgn0020385	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_005167203.1	Gene:	mthfd2l / 327496	ZFINID:	ZDB-GENE-030131-5707	Length:	348	Species:	Danio rerio

Alignment Length:	303	Identity:	117/303 - (38%)
Similarity:	180/303 - (59%)	Gaps:	15/303 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 AIKMSGAKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATE 96
            ::|...|.::||..:|:.|.:|:::::..:..: .:..|.|.::.||....|:.|:|.|.:.|:.
Zfish    45 SLKRHVATVVSGAELARQIHKEVQSDIAKLVAE-GNRRPHLSVILVGDDHASHTYVRNKTRTASL 108

  Fly    97 IGIDAAHVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGL 161
            :|:.::.:..|.|:::.|:|:.|:..|.|..:.|::||:||  ...|:...|.:||:|||||||.
Zfish   109 LGMSSSTIFRPSSVSQEEMLELIDKFNRDRNISGLLVQLPL--PEHINERAICNAVAPEKDVDGF 171

  Fly   162 HTVNEGRLAIGDLGGFLPCTPWGCLELIRRSGVEIAGARAVVLGRSKIVGTPAAELL-------- 218
            |.||.|:|.: |....:|.|.....|:|||:|:|..|...:|:||||.||.|.|.||
Zfish   172 HIVNIGKLCL-DQRCMIPATAAAVWEIIRRTGLETVGKNVLVVGRSKNVGMPIAMLLHSDRKHER 235

  Fly   219 KWANATVTVCHSKT--RNLEEITRSADILVVGIGVAEMVKGSWIKPGAVVIDCGINVKPDASKAS 281
            ...:|||.:.|..|  ..|:|:.|.|||::...||..::....:|.||.|||.|||...|.....
Zfish   236 SGGDATVIMAHRCTPLPRLKELARLADIVIAAAGVPHLITADMVKEGAAVIDVGINRMQDPVTGK 300

  Fly   282 GSKLVGDVDYAEALQVAGHLTPVPGGVGPMTVAMLMKNTVRSA 324
             |:||||||:....:.||.:|||||||||||:||:|||||.:|
Zfish   301 -SRLVGDVDFEAVKEKAGFITPVPGGVGPMTIAMVMKNTVTAA 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pug	NP_001014614.1	FolD	39..330	CDD:223268	115/296 (39%)
		THF_DHG_CYH	40..159	CDD:279147	35/118 (30%)
		NAD_bind_m-THF_DH_Cyclohyd	154..324	CDD:133448	83/179 (46%)
		FTHFS	350..968	CDD:279592
mthfd2l	XP_005167203.1	PRK14190	50..343	CDD:184560	116/298 (39%)
		THF_DHG_CYH	53..169	CDD:279147	35/118 (30%)
		NAD_bind_m-THF_DH_Cyclohyd	164..343	CDD:133448	84/181 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592534
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740