DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pug and Mthfd1l

DIOPT Version :9

Sequence 1:NP_001014614.1 Gene:pug / 41279 FlyBaseID:FBgn0020385 Length:968 Species:Drosophila melanogaster
Sequence 2:NP_001164256.1 Gene:Mthfd1l / 270685 MGIID:1924836 Length:977 Species:Mus musculus


Alignment Length:927 Identity:490/927 - (52%)
Similarity:634/927 - (68%) Gaps:31/927 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 IREELRNE---VTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEIGIDAAHVQLPRSIT 111
            :|:.:.|.   ::.:.::...|.|.|.::|.|   |.|:...|....|.|.|:|..|:.||....
Mouse    74 VRDVIHNSKEVLSLLQEKNPAFKPVLVVIQAG---DDNLMKDMNQNLAKEAGLDITHICLPPDSG 135

  Fly   112 EVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTVNEGRLAIGDLGG 176
            |.|::|:|..:||||||||:.:|:..|.    .|:::.:|:.|||||||:..:|.|:|..||...
Mouse   136 EDEIIDEILKINEDPRVHGLTLQISEDS----LSNKVLNALKPEKDVDGVTDINLGKLVRGDAPE 196

  Fly   177 -FLPCTPWGCLELIRRSGVEIAGARAVVLGRSKIVGTPAAELLKW---ANATVTV-CHSKTRNLE 236
             |:.......:||:.:||:.:.|.:.:|:|    ...|....|:|   ...::|: |...|..|.
Mouse   197 CFVSPLAKAAVELVEKSGITLDGKKVLVVG----AHGPLEAALQWLFQRKGSMTMSCPWATPQLP 257

  Fly   237 EITRSADILVVGIGVAEMVKGSWIKPGAVVIDCGINVKPDASKASGSKLVGDVDYAEALQVAGHL 301
            :..|.|||:|:|....|.:...||..|..:::|..:..  :.|.||......||...|.:     
Mouse   258 DKLREADIVVLGSPKPEEIPAVWIPSGTTILNCFHDFL--SGKLSGGSPGVPVDKLIAEE----- 315

  Fly   302 TPVPGGVGPMTVAMLMKNTVRSAARFLERLAKSQWALQTLPLKPQRPVPSDIVIARAQKPKDIAV 366
                 .|..:..|:.::|.|.|..|:|......:|.|..|.|:|..||||||.|:|.|.||.:.|
Mouse   316 -----SVSLLAAALRIQNMVSSGRRWLREQQHRRWRL
HCLKLQPLSPVPSDIEISRGQTPKAVDV 375

  Fly   367 LAKEIGLEAREVSLYGNKKAKISLSVLERLKDKEVGHYVVVAGMTPTPLGEGKTTTLMGLVQALG 431
            |||||||.|.|:.:||..|||:.||:||||||:..|.||:|||:|||||||||:|..:||||||.
Mouse   376 LAKEIGLLADEIEIYGKSKAKVQLSLLERLKDQTDGKYVLVAGITPTPLGEGKSTVTIGLVQALT 440

  Fly   432 AHKLRNTMAALRQPSQGPTFGIKGGAAGGGYAQVIPMEEFNLHLTGDIHAVSAANNLLAAQLDTR 496
            ||...|:.|.|||||||||||:||||||||||||||||||||||||||||::||||||||.:|||
Mouse   441 AHLKVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTR 505

  Fly   497 IFHENTQKDKALYDRLVPAIKGQRKFSPIQLRRLQKLGITKTDPDTLTADEYGPFARLDIDPDTI 561
            |.||:||.|||||:||||.:.|.|:||.|||.||:||||.||||.|||.:|...||||:|||.||
Mouse   506 ILHESTQTDKALYNRLVPLVNGVREFSEIQLSRLKKLGIHKTDPSTLTEEEVRKFARLNIDPATI 570

  Fly   562 MWERVVDINDRYLRTITVGQSPTEKGISRETRFSISVASEIMAVLALSRSLEDMKQRLADMVVAF 626
            .|:||:|.|||:||.||:||..||||.||:.:|.|:|||||||||||:.||.|||:||..||||.
Mouse   571 TWQRVLDTNDRFLRKITIGQGSTEKGYSRQAQFDIAVASEIMAVLALTDSLTDMKERLGRMVVAS 635

  Fly   627 DKRGKPVTADDLGVTGALAVLLKDALEPNLMQSLEGTPVLVHAGPFANIAHGCNSIIADEVGLKL 691
            ||.|:||||:||||||||.||:|||::|||||:||||||.||||||||||||.:|::||::.|||
Mouse   636 DKDGQPVTAEDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKL 700

  Fly   692 VGKNGFVCTEAGFGSDIGMEKFCNIKCRTSGRKPNAMVLVATVRAIKMHGGGAPVTPGAPLNKQY 756
            ||:.|||.||||||:|||||||.|||||.||..||.:||||||||:||||||..||.|.||.|:|
Mouse   701 VGEEGFVVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEY 765

  Fly   757 TEENLELVQKGLPNLLQHIENGKAFGMPVVVSLNAHSADTPAEHELVKKAALEAGAFAAVVSTHW 821
            ||||::||..|..||.:.|:..:.||:||||:||....||.||.:||.:.|..||||.||...||
Mouse   766 TEENIQLVADGCCNLQKQIQIAQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHW 830

  Fly   822 ADGGAGAVQLADAVIKACEQGNQFRLLYDLELPLVDKMNKIATTMYGAGKVVLSPAAEEKVKRLT 886
            :.||.|:|.||.||.:|..:.::|:.|||::||:|:|:..||.|:|||..:.|||.|:.|:.|.|
Mouse   831 SAGGKGSVDLARAVREAANKRSRFQFLYDVQLPIVEKIRVIAQTVYGAKDIELSPEAQSKIDRYT 895

  Fly   887 DAGFGNLPICMSKVSGSFTGDAKIKGAPKGFTLDVEDVYVSAGAGFVVAMCGEVTKMPGLPTRPA 951
            ..|||||||||:|...|.:.:...||.|:.|||.:.||..|.||||:..:.|.::.||||||||.
Mouse   896 QQGFGNLPICMAKTHLSLSHEPDKKGVPRDFTLPISDVRASIGAGFIYPLVGTMSTMPGLPTRPC 960

  Fly   952 IYDIDLNTETGEIEGLF 968
            .|||||:|||.:::|||
Mouse   961 FYDIDLDTETEQVKGLF 977

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pugNP_001014614.1 FolD 39..330 CDD:223268 84/287 (29%)
THF_DHG_CYH 40..159 CDD:279147 37/111 (33%)
NAD_bind_m-THF_DH_Cyclohyd 154..324 CDD:133448 48/174 (28%)
FTHFS 350..968 CDD:279592 397/617 (64%)
Mthfd1lNP_001164256.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 29..71
Methylenetetrahydrofolate dehydrogenase and cyclohydrolase 32..347 85/295 (29%)
THF_DHG_CYH 73..179 CDD:279147 37/111 (33%)
FolD 82..>287 CDD:223268 68/215 (32%)
THF_DHG_CYH_C 182..337 CDD:280955 43/170 (25%)
Formyltetrahydrofolate synthetase 348..977 402/628 (64%)
PLN02759 351..977 CDD:178359 401/625 (64%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 786 1.000 Domainoid score I74
eggNOG 1 0.900 - - E1_COG2759
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53867
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001266
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100216
Panther 1 1.100 - - O PTHR48099
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X878
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
98.780

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